Nakanuma Y, Terada T, Ohtake S, Govindarajan S
Second Department of Pathology, Kanazawa University School of Medicine, Japan.
Acta Pathol Jpn. 1988 Mar;38(3):281-9. doi: 10.1111/j.1440-1827.1988.tb02301.x.
Degenerative epithelial changes with cytoplasmic eosinophilia and nuclear pleomorphism were found in the intrahepatic periductal glands in two patients who died following allogeneic bone marrow transplantation. These changes, which have not been described in the literature to our knowledge, were closely associated with clinicopathologic signs of graft-versus-host disease (GVHD), and histologically they resembled small bile ductal lesions, a characteristic finding of hepatic GVHD. In addition, periductal glandular and small bile ductal lesions frequently coexisted. Neither livers from patients given autologous marrow transplantation nor other control livers including those from patients given abdominal irradiation revealed such glandular lesions. These results suggest that the observed changes in the intrahepatic periductal glands were a manifestation of GVHD.
在两例异基因骨髓移植后死亡的患者的肝内导管周围腺体中发现了具有细胞质嗜酸性变和核多形性的退行性上皮改变。据我们所知，这些改变在文献中尚未有描述，它们与移植物抗宿主病（GVHD）的临床病理体征密切相关，并且在组织学上类似于肝GVHD的特征性表现——小胆管病变。此外，导管周围腺体病变和小胆管病变经常同时存在。接受自体骨髓移植患者的肝脏以及其他对照肝脏，包括接受腹部照射患者的肝脏，均未发现此类腺体病变。这些结果表明，观察到的肝内导管周围腺体的改变是GVHD的一种表现。
