Kono N, Terada T, Nakanuma Y
Second Department of Pathology, Kanazawa University School of Medicine, Japan.
Gastroenterol Jpn. 1991 Apr;26(2):194-200. doi: 10.1007/BF02811080.
The anatomy and pathology of the intrahepatic peribiliary glands were evaluated. In this study, we ultrastructuraly examined the peribiliary glands of normal and hepatolithiatic livers using common and serial ultrathin section observations. It is well known that these glands proliferate markedly in hepatolithiasis. These glands were composed of several acini surrounded by thickened and multilayered basement membranes, and there were mesenchymal cells (the majority were fibroblasts) in the periacinar fibrous connective tissue. Some cytoplasmic processes of acinar epithelial cells and mesenchymal cells in the periacinar connective tissue were in close contact with each other within the thickened and multilayered basement membranes. Such cell-to-cell interaction was most frequent in cases of hepatolithiasis, in which peribiliary glands proliferated markedly. In hepatolithiatic livers, some unmyelinated nerve fibers or axonal button profiles were in close contact with periacinar mesenchymal cells and also with cytoplasmic processes of glandular epithelial cells. Such contacts were rare in normal livers. These findings suggest that such epithelial and mesenchymal cell interactions and innervations play a part in the normal regulation of peribiliary glands and also in the proliferation of peribiliary glands in hepatolithiasis.
对肝内胆管周围腺体的解剖结构和病理情况进行了评估。在本研究中，我们通过普通及连续超薄切片观察，对正常肝脏和肝内胆管结石肝脏的胆管周围腺体进行了超微结构检查。众所周知，这些腺体在肝内胆管结石病中会显著增生。这些腺体由几个腺泡组成，周围有增厚的多层基底膜，腺泡周围的纤维结缔组织中有间充质细胞（大多数为成纤维细胞）。在增厚的多层基底膜内，腺泡上皮细胞和腺泡周围结缔组织中的间充质细胞的一些细胞质突起相互紧密接触。这种细胞间相互作用在肝内胆管结石病中最为常见，此时胆管周围腺体显著增生。在肝内胆管结石肝脏中，一些无髓神经纤维或轴突终扣与腺泡周围间充质细胞以及腺上皮细胞的细胞质突起紧密接触。这种接触在正常肝脏中很少见。这些发现表明，这种上皮细胞与间充质细胞的相互作用和神经支配在胆管周围腺体的正常调节以及肝内胆管结石病中胆管周围腺体的增生过程中发挥了作用。
