Burrows R F, Caco C C, Kelton J G
Department of Obstetrics & Gynecology, McMaster University Medical Centre, Hamilton, Ontario, Canada.
Am J Hematol. 1988 Jun;28(2):98-102. doi: 10.1002/ajh.2830280207.
Neonatal alloimmune thrombocytopenia is an uncommon but important cause of thrombocytopenia in infants. Because of the severity of the thrombocytopenia, some of these infants will have intracranial hemorrhage with resultant long-term disability. Obstetricians and neonatologists have recommended delivery by caesarean section and the rapid institution of appropriate treatment for the infant; however, it is theoretically possible that a hemorrhagic event could precede the delivery and consequently not be prevented by these perinatal interventions. In this report we describe a neonate in whom the diagnosis of alloimmune neonatal thrombocytopenia was suspected because of antenatal ultrasound evidence of intracerebral hemorrhage. This case demonstrates the importance of antenatal fetal assessment and indicates the need for the development of therapeutic strategies to maintain fetal hemostasis.
新生儿同种免疫性血小板减少症是婴儿血小板减少症的一个不常见但重要的病因。由于血小板减少症的严重性，其中一些婴儿会发生颅内出血，导致长期残疾。产科医生和新生儿科医生建议剖宫产分娩并迅速对婴儿进行适当治疗；然而，理论上出血事件可能在分娩前发生，因此这些围产期干预措施无法预防。在本报告中，我们描述了一名因产前超声显示颅内出血而疑似患有同种免疫性新生儿血小板减少症的新生儿。该病例证明了产前胎儿评估的重要性，并表明需要制定维持胎儿止血的治疗策略。
