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Gastroenterology Res. 2018 Aug;11(4):264-273. doi: 10.14740/gr1062w. Epub 2018 Feb 8.
3
Characteristics and prognosis of Japanese colorectal cancer patients: The BioBank Japan Project.日本结直肠癌患者的特征与预后：日本生物银行项目
J Epidemiol. 2017 Mar;27(3S):S36-S42. doi: 10.1016/j.je.2016.12.004. Epub 2017 Feb 15.
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Ninein is essential for apico-basal microtubule formation and CLIP-170 facilitates its redeployment to non-centrosomal microtubule organizing centres.九蛋白对于顶-基微管的形成至关重要，而CLIP-170有助于其重新部署至非中心体微管组织中心。
Open Biol. 2017 Feb;7(2). doi: 10.1098/rsob.160274.
5
Cell-Type-Specific Alternative Splicing Governs Cell Fate in the Developing Cerebral Cortex.细胞类型特异性可变剪接调控发育中的大脑皮层中的细胞命运。
Cell. 2016 Aug 25;166(5):1147-1162.e15. doi: 10.1016/j.cell.2016.07.025.
6
Loss of function of the Drosophila Ninein-related centrosomal protein Bsg25D causes mitotic defects and impairs embryonic development.果蝇九蛋白相关中心体蛋白Bsg25D功能丧失会导致有丝分裂缺陷并损害胚胎发育。
Biol Open. 2016 Aug 15;5(8):1040-51. doi: 10.1242/bio.019638.
7
Cancer in Japan: Prevalence, prevention and the role of heterocyclic amines in human carcinogenesis.日本的癌症：患病率、预防以及杂环胺在人类致癌过程中的作用。
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8
The Seckel syndrome and centrosomal protein Ninein localizes asymmetrically to stem cell centrosomes but is not required for normal development, behavior, or DNA damage response in Drosophila.Seckel综合征与中心体蛋白Ninein不对称定位于干细胞中心体，但对果蝇的正常发育、行为或DNA损伤反应并非必需。
Mol Biol Cell. 2016 Jun 1;27(11):1740-52. doi: 10.1091/mbc.E15-09-0655. Epub 2016 Apr 6.
9
Human genetic variation database, a reference database of genetic variations in the Japanese population.人类遗传变异数据库，一个关于日本人群体遗传变异的参考数据库。
J Hum Genet. 2016 Jun;61(6):547-53. doi: 10.1038/jhg.2016.12. Epub 2016 Feb 25.
10
A centrosomal route for cancer genome instability.中心体途径导致癌症基因组不稳定。
Nat Cell Biol. 2014 Jun;16(6):504-6. doi: 10.1038/ncb2978.

人类第1111位密码子处的NINEIN多态性与结直肠癌风险相关。

Human NINEIN polymorphism at codon 1111 is associated with the risk of colorectal cancer.

作者信息

Yasuda Yukiko, Sakai Akiko, Ito Sachio, Sasai Kaori, Ishizaki Akisada, Okano Yoshiya, Kawahara Seito, Jitsumori Yoshimi, Yamamoto Hiromasa, Matsubara Nagahide, Shimizu Kenji, Katayama Hiroshi

机构信息

Department of Molecular Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.

Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.

出版信息

Biomed Rep. 2020 Nov;13(5):45. doi: 10.3892/br.2020.1352. Epub 2020 Aug 27.

DOI:10.3892/br.2020.1352
PMID:32934817
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7469573/
Abstract

NINEIN serves an essential role in centrosome function as a microtubule organizing center, and in the reformation of the interphase centrosome architecture following mitosis. In the present study, the association between Pro1111Ala (rs2236316), a missense single nucleotide polymorphism, and the risk of colorectal cancer (CRC), related to smoking and alcohol consumption habits in 200 patients with CRC and 1,141 cancer-free control participants were assessed in a case-control study performed in Japan. The results showed that the Ala/Ala genotype compared with the Pro/Pro genotype was significantly more associated with an increased risk of CRC, and the males with the Ala/Ala genotype exhibited a significantly increased risk of CRC compared with those with Pro/Pro and Pro/Ala genotypes. Stratified analyses of the Ala/Ala genotype with CRC risk further showed an increased association in never/light drinkers (<23 g of ethanol/day), in male never/light drinkers and in male patients with rectal cancer. These findings suggest that the genetic variant of the Pro1111Ala polymorphism has a significant effect on CRC susceptibility in the Japanese population.

摘要

NINEIN作为微管组织中心在中心体功能中发挥着重要作用，并且在有丝分裂后间期中心体结构的重塑中也发挥着重要作用。在本研究中，在日本进行的一项病例对照研究中，评估了错义单核苷酸多态性Pro1111Ala（rs2236316）与200例结直肠癌（CRC）患者和1141名无癌对照参与者的吸烟和饮酒习惯相关的结直肠癌（CRC）风险之间的关联。结果表明，与Pro/Pro基因型相比，Ala/Ala基因型与CRC风险增加显著相关，并且与Pro/Pro和Pro/Ala基因型的男性相比，Ala/Ala基因型的男性患CRC的风险显著增加。对Ala/Ala基因型与CRC风险进行分层分析进一步表明，从不饮酒/少量饮酒者（<23克乙醇/天）、男性从不饮酒/少量饮酒者以及男性直肠癌患者中的关联增加。这些发现表明，Pro1111Ala多态性的基因变异对日本人群的CRC易感性有显著影响。