Freundlich B, Makover D, Maul G G
University of Pennsylvania, Philadelphia.
Ann Intern Med. 1988 Aug 15;109(4):295-7. doi: 10.7326/0003-4819-109-4-295.
The association of malignancy with lupus-like syndromes is rare, and the relation between these two processes is uncertain. A 71-year-old woman who presented with serositis, Raynaud phenomenon, and positive results on an antinuclear antibody test was initially thought to have systemic lupus erythematosus but was found to have ovarian adenocarcinoma. A unique sparsely speckled antinuclear antibody pattern was seen. The patient's sera reacted to novel antigens with six bands of 100, 80-78, 48, and 17 kD on Western blots not typical of reactivity for sera from patients with systemic lupus erythematosus.
恶性肿瘤与狼疮样综合征的关联较为罕见，且这两个过程之间的关系尚不确定。一名71岁女性，出现浆膜炎、雷诺现象，抗核抗体检测结果呈阳性，最初被认为患有系统性红斑狼疮，但后来发现患有卵巢腺癌。观察到一种独特的稀疏斑点状抗核抗体模式。在免疫印迹中，患者血清与新抗原发生反应，出现了100、80 - 78、48和17 kD的六条带，这并非系统性红斑狼疮患者血清典型的反应性。
