宏基因组测序用于检测新冠病毒疑似感染者中的呼吸道病毒。
Metagenomic sequencing to detect respiratory viruses in persons under investigation for COVID-19.
作者信息
Babiker Ahmed, Bradley Heath, Stittleburg Victoria, Key Autum, Kraft Colleen Suzanne, Waggoner Jesse, Piantadosi Anne
出版信息
medRxiv. 2020 Sep 10:2020.09.09.20178764. doi: 10.1101/2020.09.09.20178764.
Abstract
We used metagenomic next-generation sequencing (mNGS) to assess the frequencies of alternative viral infections in SARS-CoV-2 RT-PCR negative persons under investigations (PUIs) (n=30) and viral co-infections in SARS-CoV-2 RT-PCR positive PUIs (n=45). mNGS identified both co-infections and alternative viral infections that were not detected by routine clinical workup.
摘要
我们使用宏基因组下一代测序（mNGS）来评估正在接受调查的2019冠状病毒病逆转录聚合酶链反应（SARS-CoV-2 RT-PCR）阴性的受检者（PUI）（n = 30）中其他病毒感染的频率，以及SARS-CoV-2 RT-PCR阳性的PUI（n = 45）中的病毒合并感染情况。mNGS鉴定出了常规临床检查未检测到的合并感染和其他病毒感染。
相似文献
1
Metagenomic sequencing to detect respiratory viruses in persons under investigation for COVID-19.宏基因组测序用于检测新冠病毒疑似感染者中的呼吸道病毒。
medRxiv. 2020 Sep 10:2020.09.09.20178764. doi: 10.1101/2020.09.09.20178764.
2
Metagenomic Sequencing To Detect Respiratory Viruses in Persons under Investigation for COVID-19.宏基因组测序在针对 COVID-19 进行调查的人群中检测呼吸道病毒。
J Clin Microbiol. 2020 Dec 17;59(1). doi: 10.1128/JCM.02142-20.
3
Quality control implementation for universal characterization of DNA and RNA viruses in clinical respiratory samples using single metagenomic next-generation sequencing workflow.采用单宏基因组新一代测序工作流程，对临床呼吸道样本中的 DNA 和 RNA 病毒进行通用特征描述的质量控制实施。
BMC Infect Dis. 2018 Oct 29;18(1):537. doi: 10.1186/s12879-018-3446-5.
4
Metagenomic Analysis Reveals Clinical SARS-CoV-2 Infection and Bacterial or Viral Superinfection and Colonization.宏基因组分析揭示了临床 SARS-CoV-2 感染以及细菌或病毒的合并感染和定植。
Clin Chem. 2020 Jul 1;66(7):966-972. doi: 10.1093/clinchem/hvaa106.
5
Bacterial and viral co-infections in patients with severe SARS-CoV-2 pneumonia admitted to a French ICU.入住法国重症监护病房的重症新型冠状病毒肺炎患者的细菌和病毒合并感染
Ann Intensive Care. 2020 Sep 7;10(1):119. doi: 10.1186/s13613-020-00736-x.
6
Metagenomic next-generation sequencing for mixed pulmonary infection diagnosis.宏基因组下一代测序在混合性肺部感染诊断中的应用。
BMC Pulm Med. 2019 Dec 19;19(1):252. doi: 10.1186/s12890-019-1022-4.
7
[Pathogen Diagnosis of a Febrile HIV Case by the Metagenomic Next-generation Sequencing].[基于宏基因组二代测序的发热HIV病例病原体诊断]
Sichuan Da Xue Xue Bao Yi Xue Ban. 2020 Mar;51(2):257-260. doi: 10.12182/20200360605.
8
Detection of Pulmonary Infectious Pathogens From Lung Biopsy Tissues by Metagenomic Next-Generation Sequencing.宏基因组下一代测序检测肺活检组织中的肺部感染病原体。
Front Cell Infect Microbiol. 2018 Jun 25;8:205. doi: 10.3389/fcimb.2018.00205. eCollection 2018.
9
Epidemiological and viral features of a cohort of SARS-CoV-2 symptomatic and asymptomatic individuals in an area of the Colombian Caribbean.哥伦比亚加勒比地区一组有症状和无症状 SARS-CoV-2 个体的流行病学和病毒特征。
Ann Clin Microbiol Antimicrob. 2020 Dec 7;19(1):58. doi: 10.1186/s12941-020-00397-5.
10
The metagenomic next-generation sequencing in diagnosing central nervous system angiostrongyliasis: a case report.宏基因组下一代测序诊断中枢神经系统血管圆线虫病：病例报告。
BMC Infect Dis. 2020 Sep 21;20(1):691. doi: 10.1186/s12879-020-05410-y.
Zotero 插件