评估500毫克和1000毫克剂量的环丙沙星治疗软下疳的效果。
Evaluation of 500- and 1,000-mg doses of ciprofloxacin for the treatment of chancroid.
作者信息
Bodhidatta L, Taylor D N, Chitwarakorn A, Kuvanont K, Echeverria P
机构信息
Department of Bacteriology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
出版信息
Antimicrob Agents Chemother. 1988 May;32(5):723-5. doi: 10.1128/AAC.32.5.723.
A randomized, double-blind study was performed comparing ciprofloxacin in a 500-mg single dose with 1,000 mg (500-mg doses given 12 h apart) for the treatment of chancroid in Thailand. Haemophilus ducreyi was isolated from 87 (48%) of 180 men with a clinical diagnosis of chancroid. For men with ulcers that were culture positive for H. ducreyi, rates of cure were 100% in the 500-mg group and 98% in the 1,000-mg group. For men with ulcers that were culture negative for H. ducreyi, rates of cure were 93% in the 500-mg group and 96% in the 1,000-mg group. The MIC of ciprofloxacin for 50% of isolates among 85 isolates of H. ducreyi was 0.007 micrograms/ml (range, 0.002 to 0.03 micrograms/ml). No significant adverse effects were detected in either group. These data indicate that both of these treatment regimens are equally effective therapies for chancroid in Thailand.
在泰国进行了一项随机双盲研究，比较了单次服用500毫克环丙沙星与分两次间隔12小时各服用500毫克（共1000毫克）治疗软下疳的效果。从180名临床诊断为软下疳的男性中，有87人（48%）分离出了杜克雷嗜血杆菌。对于杜克雷嗜血杆菌培养呈阳性的溃疡男性患者，500毫克组的治愈率为100%，1000毫克组为98%。对于杜克雷嗜血杆菌培养呈阴性的溃疡男性患者，500毫克组的治愈率为93%，1000毫克组为96%。在85株杜克雷嗜血杆菌分离株中，50%分离株对环丙沙星的最低抑菌浓度为0.007微克/毫升（范围为0.002至0.03微克/毫升）。两组均未检测到明显的不良反应。这些数据表明，这两种治疗方案在泰国治疗软下疳方面同样有效。
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