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MAGE-C2/CT10 通过上调前列腺癌细胞中 c-Myc 的表达促进肿瘤生长和转移。

MAGE-C2/CT10 promotes growth and metastasis through upregulating c-Myc expression in prostate cancer.

机构信息

Center of Clinical Laboratory, The First Affiliated Hospital of Soochow University, No. 899 Pinghai Road, Suzhou, 215000, Jiangsu, China.

Department of Imaging, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, No. 26 Shengli Street, Jiangan District, Wuhan, 430014, Hubei, China.

出版信息

Mol Cell Biochem. 2021 Jan;476(1):1-10. doi: 10.1007/s11010-020-03814-7. Epub 2020 Jul 6.

DOI:10.1007/s11010-020-03814-7
PMID:32935296
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7867546/
Abstract

Prostate cancer (PC) is the most common reproductive cancer in men and the third leading cause of cancer death among men worldwide. Recently targeted therapy showed a significant therapeutic effect on PC, whereas finding more PC therapeutic target is still urgently needed. Melanoma-associated antigen-encoding C2 (MAGE-C2/CT10), which have significant homology with the MAGE-C1/CT-7 gene, was known to be involved in the development of a variety of tumors. However, the role and mechanism of MAGE-C2/CT10 in prostate cancer remains unclear. Herein, we found the high levels of MAGE-C2/CT10 in highly metastatic prostate cancer. Our findings confirmed that the depletion of MAGE-C2/CT10 suppressed the growth of PC cells, and restrained PC cell migration and invasion in vitro. We noticed MAGE-C2/CT10 could stimulate c-Myc expression via FBP1, and further contributed to PC cell proliferation and motility. Performing in vivo assays, we demonstrated MAGE-C2/CT10 promoted tumor growth and metastasis of PC cells in mice. Collectively, we found the abnormal expression of MAGE-C2/CT10 in PC, and revealed the regulatory mechanism underlying MAGE-C2/CT10 promoting PC progression and metastasis.

摘要

前列腺癌（PC）是男性中最常见的生殖系统癌症，也是全球男性癌症死亡的第三大主要原因。最近的靶向治疗对 PC 显示出显著的治疗效果，然而，寻找更多的 PC 治疗靶点仍然是迫切需要的。黑色素瘤相关抗原编码 C2（MAGE-C2/CT10）与 MAGE-C1/CT-7 基因具有显著同源性，已知参与多种肿瘤的发生。然而，MAGE-C2/CT10 在前列腺癌中的作用和机制尚不清楚。在此，我们发现高度转移性前列腺癌中 MAGE-C2/CT10 水平较高。我们的研究结果证实，MAGE-C2/CT10 的缺失抑制了 PC 细胞的生长，并抑制了 PC 细胞的体外迁移和侵袭。我们注意到 MAGE-C2/CT10 可以通过 FBP1 刺激 c-Myc 表达，进一步促进 PC 细胞的增殖和迁移。进行体内实验，我们证明 MAGE-C2/CT10 促进了小鼠 PC 细胞的肿瘤生长和转移。综上所述，我们发现 MAGE-C2/CT10 在 PC 中异常表达，并揭示了 MAGE-C2/CT10 促进 PC 进展和转移的调节机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d25/7867546/21980421da78/11010_2020_3814_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d25/7867546/76bda35ae7f9/11010_2020_3814_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d25/7867546/03068f47ce50/11010_2020_3814_Fig2_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d25/7867546/bf39778cbe3d/11010_2020_3814_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d25/7867546/74947854694f/11010_2020_3814_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d25/7867546/a7f8785b867d/11010_2020_3814_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d25/7867546/21980421da78/11010_2020_3814_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d25/7867546/76bda35ae7f9/11010_2020_3814_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d25/7867546/03068f47ce50/11010_2020_3814_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d25/7867546/764a6fbb4fa7/11010_2020_3814_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d25/7867546/bf39778cbe3d/11010_2020_3814_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d25/7867546/74947854694f/11010_2020_3814_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d25/7867546/a7f8785b867d/11010_2020_3814_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d25/7867546/21980421da78/11010_2020_3814_Fig7_HTML.jpg

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本文引用的文献

1
A systematic review and meta-analysis of the diagnostic accuracy of biparametric prostate MRI for prostate cancer in men at risk.系统评价和荟萃分析双参数前列腺 MRI 对有前列腺癌风险男性的诊断准确性。
Prostate Cancer Prostatic Dis. 2021 Sep;24(3):596-611. doi: 10.1038/s41391-020-00298-w. Epub 2020 Nov 20.
2
The c-Myc/miR-27b-3p/ATG10 regulatory axis regulates chemoresistance in colorectal cancer.c-Myc/miR-27b-3p/ATG10 调控轴调控结直肠癌的化疗耐药性。
Theranostics. 2020 Jan 12;10(5):1981-1996. doi: 10.7150/thno.37621. eCollection 2020.
3
Androgen deprivation therapy for prostate cancer and the risk of hematologic disorders.
FBP1 通过参与卵巢癌中的 C-MYC/STAT3 信号轴来调节增殖、转移和化疗耐药性。
Oncogene. 2021 Oct;40(40):5938-5949. doi: 10.1038/s41388-021-01957-5. Epub 2021 Aug 6.
雄激素剥夺疗法治疗前列腺癌与血液系统疾病风险。
PLoS One. 2020 Feb 19;15(2):e0229263. doi: 10.1371/journal.pone.0229263. eCollection 2020.
4
The Adverse Effects of Androgen Deprivation Therapy in Prostate Cancer and the Benefits and Potential Anti-oncogenic Mechanisms of Progressive Resistance Training.雄激素剥夺疗法在前列腺癌中的不良反应以及渐进性抗阻训练的益处和潜在抗癌机制
Sports Med Open. 2020 Feb 13;6(1):13. doi: 10.1186/s40798-020-0242-8.
5
Salvage therapy at biochemical recurrence of prostate cancer.前列腺癌生化复发时的挽救性治疗。
Nat Rev Urol. 2020 Apr;17(4):195-196. doi: 10.1038/s41585-020-0290-3.
6
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7
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