Department of Diabetes & Endocrinology, John Hunter Hospital, Newcastle, New South Wales, Australia.
Department of Obstetrics, John Hunter Hospital, Newcastle, New South Wales, Australia.
Aust N Z J Obstet Gynaecol. 2021 Feb;61(1):142-146. doi: 10.1111/ajo.13254. Epub 2020 Sep 16.
International guidelines recommend screening for overt diabetes in early pregnancy. Women in their first trimester with fasting plasma glucose (FPG) levels that would be diagnostic of gestational diabetes mellitus (GDM) in later pregnancy are being identified and treated despite uncertainty regarding the risks and benefits. The evidence for the current diagnostic criteria and management recommendations in early GDM are reviewed. The results of a prospective observational study assessing the progression to GDM and prespecified maternal-fetal outcomes in women with mild fasting hyperglycaemia in the first trimester suggest that women with FPG 5.1-5.6 mmol/L may warrant proactive management in early pregnancy.
国际指南建议在孕早期筛查显性糖尿病。尽管对于风险和益处存在不确定性，但对于在孕晚期会被诊断为妊娠期糖尿病（GDM）的空腹血糖（FPG）水平较高的初孕妇，仍会进行识别和治疗。本文回顾了当前在早期 GDM 中诊断标准和管理建议的证据。一项前瞻性观察性研究评估了在孕早期存在轻度空腹高血糖的妇女进展为 GDM 和预设母婴结局的结果表明，FPG 为 5.1-5.6mmol/L 的妇女可能需要在孕早期进行积极的管理。
