Department of Chemistry, Indian Institute of Technology (Indian School of Mines) Dhanbad, Dhanbad-826004, India.
Chem Commun (Camb). 2020 Oct 11;56(79):11749-11762. doi: 10.1039/d0cc04264a. Epub 2020 Sep 16.
The 7-azaindole building block has attracted considerable interest in the field of drug discovery in the current portfolio. Because of their powerful medicinal properties, the development of synthetic, elegant techniques for the functionalization of 7-azaindoles continues to be an active area of research. Advances in metal-catalyzed chemistry have recently supported the successful development of a number of novel and effective methods for functionalization of the 7-azaindole template. This review reports state-of-the-art functionalization chemistry of 7-azaindoles with an aspiration to highlight the global ring functionalization of 7-azaindoles that are potential as pharmacophores for various therapeutic targets. Other relevant reviews focused on 7-azaindole synthesis, properties and applications have also been reported. However, none of these reviews have been dedicated to the results achieved in the field of metal-catalyzed cross-coupling/C-H bond functionalized reactions. So we wish to discuss and summarize the advances made since 2011 in this field toward 7-azaindole functionalization.
7-氮茚砌块在当前药物研发领域引起了相当大的兴趣。由于其强大的药用特性，开发用于 7-氮茚的合成、优雅的功能化技术仍然是一个活跃的研究领域。金属催化化学的进展最近支持了许多新型和有效的 7-氮茚模板功能化方法的成功发展。本综述报道了 7-氮茚的最新功能化化学，旨在突出全球环功能化的 7-氮茚，这些 7-氮茚作为各种治疗靶点的药效团具有潜力。其他相关的综述也集中在 7-氮茚的合成、性质和应用上。然而，这些综述都没有专门针对 2011 年以来在金属催化交叉偶联/C-H 键功能化反应领域取得的成果。因此，我们希望讨论和总结 2011 年以来在 7-氮茚功能化方面取得的进展。
