Doerfler W
Institut für Genetik, Universität zu Köln.
Arzneimittelforschung. 1988 Mar;38(3A):442-8.
This paper presents an introduction into basic principles of antiviral therapy. At the outset, the essential features of virus-host cell interactions have been described to facilitate a discussion of possibilities for antiviral therapy. Subsequently, the most important groups of viruses are evaluated according to the underlying mechanisms of replication (Baltimore classification). The rather limited examples of successful antiviral therapy have been documented. Elementary problems remain unresolved: How can viral replication steps be intercepted without afflicting host mechanisms? Finally, hypothetical approaches towards the elimination of persisting viral genomes from the cellular genome have been reviewed.
本文介绍了抗病毒治疗的基本原理。首先，描述了病毒与宿主细胞相互作用的基本特征，以便于讨论抗病毒治疗的可能性。随后，根据复制的潜在机制（巴尔的摩分类法）对抗病毒治疗的最重要的病毒类别进行了评估。已记录了相当有限的成功抗病毒治疗的例子。基本问题仍未解决：如何在不影响宿主机制的情况下阻断病毒复制步骤？最后，回顾了从细胞基因组中消除持续存在的病毒基因组的假设方法。
