Bao Qiao-Fei, Xia Yu, Li Ming, Wang Yu-Zhao, Liang Yong-Min
State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China.
Urumqi Key Laboratory of Green Catalysis and Synthesis Technology, College of Chemistry, Xinjiang University, Urumqi 830046, P. R. China.
Org Lett. 2020 Oct 2;22(19):7757-7761. doi: 10.1021/acs.orglett.0c03022. Epub 2020 Sep 16.
Difunctionalization of alkenes is a valuable tool for the synthesis of complicated compounds from simple precursors. Herein, a feasible method for the construction of β-trifluoromethyl-α-substituted alcohols under visible-light-induced metal-free conditions is described. This catalytic system exhibits mild reaction conditions and good compatibility of functional groups. Trifluoromethyl and alcohols are valuable structural motifs due to their unique biological properties, and this work shows the potential application in the realm of pharmacy and organic synthesis.
烯烃的双官能化是一种从简单前体合成复杂化合物的重要工具。本文描述了一种在可见光诱导的无金属条件下构建β-三氟甲基-α-取代醇的可行方法。该催化体系反应条件温和，官能团兼容性良好。三氟甲基和醇因其独特的生物学性质而成为有价值的结构单元，这项工作展示了其在药学和有机合成领域的潜在应用。
