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1
Antagonism of N-methylaspartate and synaptic responses of neurones in the rat ventrobasal thalamus by ketamine and MK-801.氯胺酮和MK-801对大鼠腹侧基底丘脑神经元N-甲基-D-天冬氨酸的拮抗作用及突触反应
Br J Pharmacol. 1988 Jun;94(2):443-8. doi: 10.1111/j.1476-5381.1988.tb11546.x.
2
Differences in results from in vivo and in vitro studies on the use-dependency of N-methylaspartate antagonism by MK-801 and other phencyclidine receptor ligands.关于MK-801及其他苯环利定受体配体对N-甲基-D-天冬氨酸拮抗作用的使用依赖性，体内研究与体外研究结果的差异。
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3
The mechanism of action and pharmacological specificity of the anticonvulsant NMDA antagonist MK-801: a voltage clamp study on neuronal cells in culture.抗惊厥性N-甲基-D-天冬氨酸（NMDA）拮抗剂MK-801的作用机制和药理学特异性：对培养神经元细胞的电压钳研究
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4
The competitive N-methyl-D-aspartate (NMDA) antagonist CGS 19755 attenuates the rate-decreasing effects of NMDA in rhesus monkeys without producing ketamine-like discriminative stimulus effects.
Eur J Pharmacol. 1989 Jan 10;159(2):133-9. doi: 10.1016/0014-2999(89)90697-3.
5
The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist.抗惊厥药物MK-801是一种有效的N-甲基-D-天冬氨酸拮抗剂。
Proc Natl Acad Sci U S A. 1986 Sep;83(18):7104-8. doi: 10.1073/pnas.83.18.7104.
6
MK-801, a proposed noncompetitive antagonist of excitatory amino acid neurotransmission, produces phencyclidine-like behavioral effects in pigeons, rats and rhesus monkeys.
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7
The role of N-methylaspartate receptors in mediating responses of rat and cat spinal neurones to defined sensory stimuli.N-甲基-D-天冬氨酸受体在介导大鼠和猫脊髓神经元对特定感觉刺激的反应中的作用。
J Physiol. 1987 Apr;385:169-88. doi: 10.1113/jphysiol.1987.sp016490.
8
Selective inhibition of synaptic versus non-synaptic epileptogenesis by NMDA antagonists in the in vitro hippocampus.
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9
MK-801 powerfully protects against N-methyl aspartate neurotoxicity.
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Ketamine and MK-801 prevent degeneration of thalamic neurons induced by focal cortical seizures.氯胺酮和MK-801可预防局灶性皮质癫痫发作诱导的丘脑神经元变性。
Exp Neurol. 1989 Sep;105(3):272-9. doi: 10.1016/0014-4886(89)90130-1.

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Cortical plasticity is associated with blood-brain barrier modulation.皮质可塑性与血脑屏障调节有关。
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2
Neuronal correlates of ketamine and walking induced gamma oscillations in the medial prefrontal cortex and mediodorsal thalamus.氯胺酮与行走在内侧前额叶皮质和丘脑背内侧核诱导的伽马振荡的神经元相关性。
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3
A Neurophysiological Perspective on a Preventive Treatment against Schizophrenia Using Transcranial Electric Stimulation of the Corticothalamic Pathway.从神经生理学角度看经颅电刺激皮质丘脑通路预防精神分裂症的治疗方法
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4
Function of non-NMDA receptors and NMDA receptors in synaptic responses to natural somatosensory stimulation in the ventrobasal thalamus.
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本文引用的文献

1
Ketamine--its pharmacology and therapeutic uses.氯胺酮——其药理学及治疗用途。
Anesthesiology. 1982 Feb;56(2):119-36. doi: 10.1097/00000542-198202000-00007.
2
The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N-methyl-aspartate.分离麻醉药氯胺酮和苯环己哌啶可选择性降低N-甲基天冬氨酸对中枢哺乳动物神经元的兴奋作用。
Br J Pharmacol. 1983 Jun;79(2):565-75. doi: 10.1111/j.1476-5381.1983.tb11031.x.
3
Opiate-like analgesic activity in general anaesthetics.全身麻醉剂中的阿片样镇痛活性。
Br J Pharmacol. 1981 Jun;73(2):435-42. doi: 10.1111/j.1476-5381.1981.tb10440.x.
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Excitatory amino acid transmitters.兴奋性氨基酸递质
Annu Rev Pharmacol Toxicol. 1981;21:165-204. doi: 10.1146/annurev.pa.21.040181.001121.
5
Effects of ketamine (CI 581) on cell responses to cutaneous stimulations in laminae IV and V in the cat's dorsal horn.氯胺酮（CI 581）对猫脊髓背角IV层和V层细胞对皮肤刺激反应的影响。
Eur J Pharmacol. 1972 May;18(3):346-52. doi: 10.1016/0014-2999(72)90035-0.
6
The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist.抗惊厥药物MK-801是一种有效的N-甲基-D-天冬氨酸拮抗剂。
Proc Natl Acad Sci U S A. 1986 Sep;83(18):7104-8. doi: 10.1073/pnas.83.18.7104.
7
Excitatory amino acid receptors and synaptic transmission in the rat ventrobasal thalamus.大鼠腹侧基底丘脑的兴奋性氨基酸受体与突触传递
J Physiol. 1987 Oct;391:499-510. doi: 10.1113/jphysiol.1987.sp016752.
8
Mediation of thalamic sensory input by both NMDA receptors and non-NMDA receptors.
Nature. 1986;322(6076):263-5. doi: 10.1038/322263a0.
9
A magnesium-sensitive post-synaptic potential in rat cerebral cortex resembles neuronal responses to N-methylaspartate.大鼠大脑皮层中对镁敏感的突触后电位类似于神经元对N-甲基-D-天冬氨酸的反应。
J Physiol. 1986 Jan;370:531-49. doi: 10.1113/jphysiol.1986.sp015949.
10
Quantitative studies on some antagonists of N-methyl D-aspartate in slices of rat cerebral cortex.大鼠大脑皮质切片中一些 N-甲基-D-天冬氨酸拮抗剂的定量研究。
Br J Pharmacol. 1985 Feb;84(2):381-91. doi: 10.1111/j.1476-5381.1985.tb12922.x.

氯胺酮和MK-801对大鼠腹侧基底丘脑神经元N-甲基-D-天冬氨酸的拮抗作用及突触反应

Antagonism of N-methylaspartate and synaptic responses of neurones in the rat ventrobasal thalamus by ketamine and MK-801.

作者信息

Salt T E, Wilson D G, Prasad S K

机构信息

Department of Physiology, University College, Cardiff.

出版信息

Br J Pharmacol. 1988 Jun;94(2):443-8. doi: 10.1111/j.1476-5381.1988.tb11546.x.

DOI:10.1111/j.1476-5381.1988.tb11546.x
PMID:3293684
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1853994/
Abstract
  1. Extracellular single neurone recordings were made in the ventrobasal thalamus of urethane-anaesthetized rats. 2. Iontophoretically and intravenously administered ketamine and MK-801 were found to be selective antagonists of responses of neurones to iontophoretically applied N-methylaspartate. 3. Both antagonists, administered in N-methylaspartate-selective quantities, reduced the synaptic responses of ventrobasal thalamus neurones to a two-second air jet directed at the peripheral receptive field.
摘要
  1. 在经乌拉坦麻醉的大鼠腹侧基底丘脑进行细胞外单神经元记录。2. 发现离子电渗法和静脉注射给予的氯胺酮和MK - 801是神经元对离子电渗法施加的N - 甲基天冬氨酸反应的选择性拮抗剂。3. 以N - 甲基天冬氨酸选择性剂量给予的这两种拮抗剂，均降低了腹侧基底丘脑神经元对指向外周感受野的两秒喷气刺激的突触反应。