验证中文版化疗诱导味觉改变量表在头颈部癌症放疗患者中的应用。

Validation of the Chinese version of chemotherapy-induced Taste Alteration Scale among patients with head and neck cancer undergoing radiotherapy.

机构信息

Division of Medical & Surgical Nursing, School of Nursing, Peking University, 100191, Beijing, China.

出版信息

Eur J Oncol Nurs. 2020 Oct;48:101818. doi: 10.1016/j.ejon.2020.101818. Epub 2020 Aug 6.

DOI:10.1016/j.ejon.2020.101818

PMID:32937262

Abstract

PURPOSE

To validate the Chinese version of the Chemotherapy-induced Taste Alteration Scale (CiTAS) among patients with head and neck cancer (HNC) undergoing radiotherapy (RT).

METHODS

Patients with HNC undergoing RT were enrolled from a cancer hospital. Data were collected by face-to-face interview. Patients' subjective taste alterations (TAs) were assessed by the CiTAS. The content validity was evaluated by five experts. Confirmatory and exploratory factor analysis were used to assess construct validity. Convergent validity was assessed by the correlation between the CiTAS score and the Quality of Life Questionnaire-Core 30 (QLQ-C30) score. A single-item subjective intensity taste alteration question and quartiles of RT duration were used to assess the discriminant validity. The reliability was assessed by the Cronbach's alpha and test-retest reliability.

RESULTS

253 patients participated this investigation and 25 patients completed twice. Confirmatory factor analysis showed that the original CiTAS structure with four dimensions was not applicable to patients with HNC undergoing RT. The Chinese version of modified-CiTAS (m-CiTAS) retained 17 items (the item "bothered by the smell of food" was deleted) loading onto three factors: decline in taste, discomfort, and phantogeusia and parageusia. The m-CiTAS showed acceptable correlations with the QLQ-C30. It could effectively discriminate the intensity of subjective TAs according to the single-item question and quartiles of RT duration. The m-CiTAS showed acceptable internal consistency (Cronbach's alpha = 0.573-0.958) and test-retest reliability (r = 0.726-0.831, P < 0.05).

CONCLUSIONS

The Chinese version of m-CiTAS is an acceptable and applicable instrument to evaluate TAs among patients with HNC undergoing RT.

摘要

目的

验证中文版化疗味觉改变量表（CiTAS）在接受放疗（RT）的头颈部癌症（HNC）患者中的适用性。

方法

从一家癌症医院招募接受 RT 的 HNC 患者。通过面对面访谈收集数据。使用 CiTAS 评估患者的主观味觉改变（TAs）。内容效度由五名专家评估。验证性和探索性因子分析用于评估结构效度。CiTAS 评分与生活质量问卷核心 30 项（QLQ-C30）评分之间的相关性用于评估聚合效度。单项主观味觉强度改变问题和 RT 持续时间的四分位数用于评估判别效度。信度通过 Cronbach's alpha 和重测信度进行评估。

结果

253 名患者参与了这项研究，其中 25 名患者完成了两次评估。验证性因子分析表明，最初的 CiTAS 结构（四个维度）不适用于接受 RT 的 HNC 患者。中文版改良-CiTAS（m-CiTAS）保留了 17 个项目（删除了“食物的气味困扰”项目），分为三个因子：味觉下降、不适和味觉幻觉和味觉倒错。m-CiTAS 与 QLQ-C30 具有良好的相关性。根据单项问题和 RT 持续时间的四分位数，它可以有效区分主观 TAs 的强度。m-CiTAS 具有可接受的内部一致性（Cronbach's alpha 为 0.573-0.958）和重测信度（r 为 0.726-0.831，P<0.05）。