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本文引用的文献

1
Inhibition of PI3K/Akt signaling suppresses epithelial-to-mesenchymal transition in hepatocellular carcinoma through the Snail/GSK-3/beta-catenin pathway.抑制 PI3K/Akt 信号通路通过 Snail/GSK-3/beta-catenin 通路抑制肝癌中的上皮间质转化。
Clin Mol Hepatol. 2020 Oct;26(4):529-539. doi: 10.3350/cmh.2019.0056n. Epub 2020 Aug 24.
2
Roles of the PI3K/AKT/mTOR signalling pathways in neurodegenerative diseases and tumours.PI3K/AKT/mTOR信号通路在神经退行性疾病和肿瘤中的作用。
Cell Biosci. 2020 Apr 1;10(1):54. doi: 10.1186/s13578-020-00416-0. eCollection 2020.
3
PI3Kδ Is a Therapeutic Target in Hepatocellular Carcinoma.PI3Kδ 在肝细胞癌中是一个治疗靶点。
Hepatology. 2018 Dec;68(6):2285-2300. doi: 10.1002/hep.30307. Epub 2018 Nov 8.
4
Glycogen synthase kinase-3β inhibition promotes lysosome-dependent degradation of c-FLIP in hepatocellular carcinoma.糖原合酶激酶-3β抑制促进肝癌细胞中 c-FLIP 的溶酶体依赖性降解。
Cell Death Dis. 2018 Feb 14;9(2):230. doi: 10.1038/s41419-018-0309-3.
5
The PI3K Pathway in Human Disease.人类疾病中的PI3K信号通路。
Cell. 2017 Aug 10;170(4):605-635. doi: 10.1016/j.cell.2017.07.029.
6
Pivotal roles of glycogen synthase-3 in hepatocellular carcinoma.糖原合酶-3在肝细胞癌中的关键作用。
Adv Biol Regul. 2017 Aug;65:59-76. doi: 10.1016/j.jbior.2017.06.002. Epub 2017 Jun 6.
7
RBMY, a novel inhibitor of glycogen synthase kinase 3β, increases tumor stemness and predicts poor prognosis of hepatocellular carcinoma.RBMY，一种糖原合成酶激酶 3β的新型抑制剂，增加肿瘤干细胞特性并预测肝细胞癌的不良预后。
Hepatology. 2015 Nov;62(5):1480-96. doi: 10.1002/hep.27996. Epub 2015 Aug 25.
8
Idelalisib: First-in-Class PI3K Delta Inhibitor for the Treatment of Chronic Lymphocytic Leukemia, Small Lymphocytic Leukemia, and Follicular Lymphoma.idelalisib：用于治疗慢性淋巴细胞白血病、小淋巴细胞白血病和滤泡性淋巴瘤的首款PI3Kδ抑制剂。
Clin Cancer Res. 2015 Apr 1;21(7):1537-42. doi: 10.1158/1078-0432.CCR-14-2034. Epub 2015 Feb 10.
9
Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer.PI(3)K p110δ 的失活破坏了调节性 T 细胞介导的对癌症的免疫耐受。
Nature. 2014 Jun 19;510(7505):407-411. doi: 10.1038/nature13444. Epub 2014 Jun 11.
10
Correlation between tuberous sclerosis complex 2 and glycogen synthase kinase 3 beta levels, and outcomes of patients with hepatocellular carcinoma treated by hepatectomy.结节性硬化症复合征 2 与糖原合成酶激酶 3β水平的相关性及其与肝癌患者肝切除术后结局的关系。
Hepatol Res. 2014 Oct;44(11):1142-50. doi: 10.1111/hepr.12256. Epub 2013 Nov 8.

Phosphoinositide 3-kinase inhibitors are effective therapeutic drugs for the treatment of hepatocellular carcinoma?

作者信息

Park Jeong Su, Bae Soo Han

机构信息

Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, Korea.

出版信息

Clin Mol Hepatol. 2020 Oct;26(4):577-578. doi: 10.3350/cmh.2020.0143. Epub 2020 Sep 17.

DOI:10.3350/cmh.2020.0143
PMID:32937686
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7641560/
Abstract
摘要