Department of Respiratory and Critical Care Medicine, Beijing Shijitan Hospital, Capital Medical University , Beijing, China.
Expert Rev Respir Med. 2020 Sep;14(9):929-936. doi: 10.1080/17476348.2020.1776613.
There was inconsistent results regarding the associations of neutrophil to lymphocyte ratio (NLR) with the progression and prognosis of chronic obstructive pulmonary disease (COPD).
This paper assess the role of NLR on the progression and prognosis of COPD using a meta-analytic approach. PubMed, EmBase, and the Cochrane library were systematically searched. The pooled weighted mean differences and odds ratios with 95% confidence intervals were applied for continuous and categorical variables using the random-effects model.
NLR was significantly high when comparing COPD patients to healthy individuals, and acute exacerbation COPD to stable COPD. Moreover, elevated NLR were significantly associated with higher risk of mortality and exacerbation.
中性粒细胞与淋巴细胞比值（NLR）与慢性阻塞性肺疾病（COPD）的进展和预后的相关性存在不一致的结果。
本文使用荟萃分析方法评估 NLR 对 COPD 进展和预后的作用。系统地检索了 PubMed、EmBase 和 Cochrane 图书馆。使用随机效应模型对连续变量和分类变量应用合并加权均数差和 95%置信区间的比值比。
与健康个体相比，COPD 患者的 NLR 明显升高，与稳定期 COPD 相比，急性加重期 COPD 的 NLR 明显升高。此外，升高的 NLR 与更高的死亡率和加重风险显著相关。
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