Röscher Pierre, van Wyk Jacqueline M
Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, 719 Umbilo Rd, Umbilo, Berea, 4001, South Africa.
Syst Rev. 2020 Sep 17;9(1):214. doi: 10.1186/s13643-020-01473-9.
Interventions to treat early prostate cancer (PCa) can leave men with debilitating sexual side effects. The cluster of side effects referred to as the neglected sexual side effects (NSSE) may remain permanent, undiagnosed and untreated because men are hesitant to disclose them. Questionnaires offer a discreet way into the discussion, subsequent diagnosis and possible treatment of the NSSE. This study will be conducted to map the evidence about the prevalence of the neglected sexual side effects (NSSE) after PCa treatment, and use of questionnaires in its diagnosis and screening.
This systematic scoping review will involve searching the following electronic databases: PubMed, Science Direct and Google Scholar. Following title searching, two-independent reviewers will conduct screening of abstracts and full articles. Eligibility criteria will guide the screenings. Data will be extracted from the included studies, and the emerging themes will be analysed. The review team will analyse the implications of the findings concerning the research question and aim of the study. The mixed method appraisal tool (MMAT) will be employed for quality appraisal of included studies.
We anticipate finding a number of studies that describe the prevalence of NSSE after early PCa treatment and that report on using questionnaires to screen for the presence of symptoms including orgasm-associated incontinence, urinary incontinence during sexual stimulation, altered perceptions of orgasm, orgasm associated pain, penile shortening and penile deformity. The study findings will be disseminated through publication in a peer-reviewed journal, peer presentations and presentations at relevant conferences.
治疗早期前列腺癌（PCa）的干预措施可能会给男性带来令人衰弱的性副作用。被称为被忽视的性副作用（NSSE）的副作用群可能会一直存在，未被诊断和治疗，因为男性不愿透露这些副作用。问卷调查为讨论、后续诊断以及可能的NSSE治疗提供了一种谨慎的方式。本研究将绘制关于PCa治疗后被忽视的性副作用（NSSE）患病率的证据，以及问卷调查在其诊断和筛查中的应用情况。
这项系统的范围综述将涉及搜索以下电子数据库：PubMed、ScienceDirect和谷歌学术。在标题搜索之后，两名独立的评审员将对摘要和全文进行筛选。纳入标准将指导筛选过程。数据将从纳入的研究中提取，并对出现的主题进行分析。综述团队将分析研究结果对研究问题和研究目的的影响。混合方法评估工具（MMAT）将用于对纳入研究的质量评估。
我们预计会找到一些描述早期PCa治疗后NSSE患病率的研究，并报告使用问卷调查来筛查包括性高潮相关尿失禁、性刺激期间尿失禁、性高潮感知改变、性高潮相关疼痛、阴茎缩短和阴茎畸形等症状的存在情况。研究结果将通过在同行评审期刊上发表、同行报告以及在相关会议上报告的方式进行传播。
