Terao I, Hagiwara T, Horie T
First Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan.
Nihon Kyobu Shikkan Gakkai Zasshi. 1993 Jan;31(1):1-6.
Serum and urinary neopterin levels were determined by high pressure liquid chromatography in 26 patients with pulmonary sarcoidosis and 12 healthy controls. Neopterin levels were significantly higher in sarcoidosis patients than in the controls. Neopterin levels differed from serum angiotensin converting enzyme (ACE) activities and were significantly higher in radiologic stage 1 and 2 than in radiologic stage 0 in patients not receiving prednisolone. No significant correlation was found between neopterin level and serum ACE activity. On the other hand, a significant correlation was found between neopterin level and serum adenosine deaminase activity. We believe that serum and urinary neopterin levels may be a more clinically valuable method of assessing pulmonary sarcoidosis than serum ACE activity.
采用高压液相色谱法测定了26例肺结节病患者和12名健康对照者的血清及尿新蝶呤水平。结节病患者的新蝶呤水平显著高于对照组。新蝶呤水平与血清血管紧张素转换酶（ACE）活性不同，在未接受泼尼松龙治疗的患者中，放射学1期和2期的新蝶呤水平显著高于放射学0期。新蝶呤水平与血清ACE活性之间未发现显著相关性。另一方面，新蝶呤水平与血清腺苷脱氨酶活性之间发现显著相关性。我们认为，血清和尿新蝶呤水平可能是一种比血清ACE活性更具临床价值的评估肺结节病的方法。
