Institute of Chemistry, Academia Sinica, Taipei, 115, Taiwan.
Chemical Biology and Molecular Biophysics Program (Taiwan), International Graduate Program (TIGP), Academia Sinica, Taipei, 115, Taiwan.
Chemistry. 2021 Feb 5;27(8):2556-2568. doi: 10.1002/chem.202003105. Epub 2020 Dec 3.
Chemical synthesis is one of the practical approaches to access carbohydrate-based natural products and their derivatives with high quality and in a large quantity. However, stereoselectivity during the glycosylation reaction is the main challenge because the reaction can generate both α- and β-glycosides. The main focus of the present article is the concept of recent mechanistic studies that have applied statistical analysis and quantitation for defining stereoselective changes during the reaction process. Based on experimental evidence, a detailed discussion associated with the mechanism and degree of influence affecting the stereoselective outcome of glycosylation is included.
化学合成是获取高质量、大量碳水化合物天然产物及其衍生物的实用方法之一。然而，糖基化反应过程中的立体选择性是主要挑战，因为该反应会同时生成α-和β-糖苷。本文的主要重点是最近的一些机制研究概念，这些研究应用了统计分析和定量方法来定义反应过程中立体选择性的变化。基于实验证据，本文包括了与影响糖基化立体选择性结果的机制和影响程度相关的详细讨论。
