Mukherjee Mana Mohan, Ghosh Rina, Hanover John A
Laboratory of Cell and Molecular Biology, NIDDK, National Institutes of Health, Bethesda, MD, United States.
Department of Chemistry, Jadavpur University, Kolkata, India.
Front Mol Biosci. 2022 Jun 14;9:896187. doi: 10.3389/fmolb.2022.896187. eCollection 2022.
Carbohydrates involving glycoconjugates play a pivotal role in many life processes. Better understanding toward glycobiological events including the structure-function relationship of these biomolecules and for diagnostic and therapeutic purposes including tailor-made vaccine development and synthesis of structurally well-defined oligosaccharides (OS) become important. Efficient chemical glycosylation in high yield and stereoselectivity is however challenging and depends on the fine tuning of a protection profile to get matching glycosyl donor-acceptor reactivity along with proper use of other important external factors like catalyst, solvent, temperature, activator, and additive. So far, many glycosylation methods have been reported including several reviews also. In the present review, we will concentrate our discussion on the recent trend on α- and β-selective glycosylation reactions reported during the past decade.
涉及糖缀合物的碳水化合物在许多生命过程中起着关键作用。更好地理解糖生物学事件，包括这些生物分子的结构 - 功能关系，以及用于诊断和治疗目的，包括定制疫苗开发和合成结构明确的寡糖（OS）变得很重要。然而，高效的化学糖基化反应要实现高产率和立体选择性具有挑战性，这取决于对保护策略的精细调整，以使糖基供体 - 受体反应性相匹配，同时正确使用其他重要的外部因素，如催化剂、溶剂、温度、活化剂和添加剂。到目前为止，已经报道了许多糖基化方法，也有几篇综述。在本综述中，我们将集中讨论过去十年中报道的α - 和β - 选择性糖基化反应的最新趋势。
