La Trobe University, College of Science, Health and Engineering, Bundoora, Victoria, Australia.
The Florey Institute of Neuroscience and Mental Health, Heidelberg, Victoria, Australia.
Neurorehabil Neural Repair. 2020 Sep;34(9):844-855. doi: 10.1177/1545968320948607.
. White blood cell (WBC) and neutrophil counts (NC) are common markers of inflammation and neurological stroke damage and could be expected to predict poststroke outcomes. . The aim of this study was to explore the prognostic value of early poststroke WBC and NC to predict cognition, mood, and disability outcomes at 3 and 12 months poststroke. . Routine clinical analyses WBC and NC were collected at 3 time points in the first 4 days of hospitalization from 156 acute stroke patients. Correlations using hierarchical or ordinal regressions were explored between acute WBC and NC and functional recovery, depression, and cognition at 3 and 12 months poststroke, after covarying for age and baseline stroke severity. . We found significant increases in NC between <12 hours and 24 to 48 hours time points ( = .05). Hierarchical regressions, covaried for age and baseline stroke severity, found that 24 to 48 hours WBC ( = .05) and NC ( = .04) significantly predicted 3-month cognition scores. Similarly, 24 to 48 hours WBC ( = .05) and NC ( = .02) predicted cognition scores at 12 months. Increases in WBC and NC were predictive of increased cognition scores at both 3 and 12 months (positive recovery) though there were no significant associations between WBC and NC and disability or depression scores. . Routine acute stroke clinical laboratory tests such as WBC and NC taken between 24 and 48 hours poststroke are predictive of cognition poststroke. It is interpreted that higher rapid immunological activation in the acute phase is an indicator for the trajectory of positive stroke recovery.
白细胞 (WBC) 和中性粒细胞计数 (NC) 是炎症和神经中风损伤的常见标志物，预计可以预测中风后的结果。本研究旨在探讨中风后早期 WBC 和 NC 的预后价值，以预测中风后 3 个月和 12 个月的认知、情绪和残疾结局。从 156 例急性中风患者住院的前 4 天内的 3 个时间点采集常规临床分析 WBC 和 NC。使用分层或有序回归分析急性 WBC 和 NC 与中风后 3 个月和 12 个月的功能恢复、抑郁和认知之间的相关性，同时调整年龄和基线中风严重程度。我们发现 NC 在<12 小时和 24 至 48 小时时间点之间显著增加（ =.05）。分层回归，同时调整年龄和基线中风严重程度，发现 24 至 48 小时 WBC（ =.05）和 NC（ =.04）显著预测 3 个月的认知评分。同样，24 至 48 小时 WBC（ =.05）和 NC（ =.02）预测 12 个月的认知评分。WBC 和 NC 的增加预测了 3 个月和 12 个月的认知评分增加（阳性恢复），尽管 WBC 和 NC 与残疾或抑郁评分之间没有显著关联。中风后 24 至 48 小时采集的常规急性中风临床实验室测试（如 WBC 和 NC）可预测中风后的认知情况。可以解释为急性期更快的免疫激活是阳性中风恢复轨迹的指标。
