Deakin University, School of Medicine, IMPACT, Institute for Innovation in Physical and Mental Health and Clinical Translation, Geelong, Australia.
Department for Management of Science and Technology Development, Ton Duc Thang University, Ho Chi Minh City, Vietnam.
Curr Pharm Des. 2021;27(4):540-547. doi: 10.2174/1381612826666200917143816.
Mucoadhesive formulations have been demonstrated to result in efficient drug delivery systems with advantages over existing systems such as increased local retention and sustained drug release via adhesiveness to mucosal tissues. The controlled release of colon-targeted, orally administered drugs has recently attracted a number of studies investigating mucoadhesive systems. Consequently, substantial designs, from mucoadhesive cores to shells of particles, have been studied with promising applications. This review will provide an overview of specific strategies for developing mucoadhesive systems for colon-targeted oral delivery with controlled drug release, including mucoadhesive matrices, cross-linked mucoadhesive microparticles, coatings and mucoadhesive nanoparticles. The understanding of the basic principle of these designs and advanced formulations throughout will lead to the development of products with efficient drug delivery at the colon for therapies for different diseases.
黏膜黏附制剂已被证明可有效递药系统，与现有系统相比具有诸多优势，如通过黏附于黏膜组织而增加局部滞留时间和药物持续释放。最近，人们对结肠定位、口服给药的控释制剂进行了大量研究，这些制剂均涉及黏膜黏附系统。因此，人们对从黏膜黏附核到粒子壳等各种设计进行了大量研究，这些设计具有广阔的应用前景。本文综述了用于结肠定位口服控释递药的黏膜黏附系统的具体策略，包括黏膜黏附基质、交联型黏膜黏附微球、包衣和黏膜黏附纳米粒。对这些设计和先进制剂的基本原理的深入了解，将有助于开发在结肠部位具有高效药物递送作用的产品，用于治疗各种疾病。
