School of Medicine, Deakin University, Geelong, Australia.
Department for Management of Science and Technology Development, Ton Duc Thang University, Ho Chi Minh City, Vietnam.
Curr Med Chem. 2021;28(10):1957-1969. doi: 10.2174/0929867327666200604170048.
Colon-targeted oral delivery has recently attracted a substantial number of studies on both systemic and local treatments. Among approaches for colonic delivery, film coatings have been demonstrated as effective elements of the drug delivery systems because they can integrate multiple release strategies, such as pH-controlled release, time-controlled release and enzyme-triggered release. Moreover, coating layer modulations, natural film materials and nanoparticle coatings have been vigorously investigated with promising applications. This review aims to describe the primary approaches for improving drug delivery to the colon in the last decade. The outstanding importance of current developments in film coatings will advance dosage form designs and lead to the development of efficient colon-targeted oral delivery systems.
结肠靶向口服给药最近引起了大量的系统和局部治疗研究。在结肠给药的方法中，薄膜包衣已被证明是药物传递系统的有效组成部分，因为它们可以整合多种释放策略，如 pH 控制释放、时间控制释放和酶触发释放。此外，涂层调制、天然膜材料和纳米粒子涂层也得到了大力研究，具有广阔的应用前景。本文综述了近十年来改善药物结肠递药的主要方法。薄膜包衣的最新发展具有突出的重要性，将推进制剂设计，并开发出有效的结肠靶向口服递药系统。
