Department of Cardiology, Institute of Field Surgery, Daping Hospital, Army Medical University, Chongqing.
Key Laboratory of Basic Pharmacology of Ministry of Education Joint International Research Laboratory of Ministry Education, Zunyi Medical University, Zunyi, China.
J Hypertens. 2021 Mar 1;39(3):453-460. doi: 10.1097/HJH.0000000000002655.
To investigate the characteristics of blood pressure in subclinical hypothyroidism by combining office blood pressure and 24-h ambulatory blood pressure.
A total of 3078 adults voluntarily participants were enrolled in this study between December 2017 and November 2019. Among 1431 of them who did not fit exclusion criteria, 104 patients were with subclinical hypothyroidism (S-HYPO group), and 1327 were euthyroid participants (euthyroid group). Office blood pressure measurement and 24-h ambulatory blood pressure monitoring were carried out to analyze the characteristics of blood pressure in subclinical hypothyroidism.
There was no statistical difference in office SBP and DBP between the S-HYPO group and the euthyroid group (P > 0.05). On the ambulatory blood pressure level, the daytime SBP, night-time SBP, night-time SBP, 24-h SBP and DBP in the S-HYPO group were significantly higher than those in the euthyroid group (P = 0.048, P = 0.002, P = 0.003, P = 0. 014, P = 0. 046, respectively), and the proportion of nondipper blood pressure in the S-HYPO group was higher than that in the euthyroid group. Comprehensive analysis of blood pressure inside and outside the joint clinic revealed that the S-HYPO group was independently related to sustained hypertension and masked hypertension but not to white-coat hypertension (P = 0.004, P = 0.002, P = 0.886, respectively). After adjusting for age, sex, BMI, and other confounding factors, the above differences were still statistically significant (P < 0.05).
The characteristics of blood pressure in subclinical hypothyroidism can be more accurately understood by combining office blood pressure and ambulatory blood pressure.
通过联合诊室血压和 24 小时动态血压来研究亚临床甲状腺功能减退症的血压特征。
本研究共纳入 2017 年 12 月至 2019 年 11 月期间的 3078 名自愿参与者。在符合排除标准的 1431 名参与者中，104 名患有亚临床甲状腺功能减退症（S-HYPO 组），1327 名为甲状腺功能正常的参与者（甲状腺功能正常组）。进行诊室血压测量和 24 小时动态血压监测，以分析亚临床甲状腺功能减退症患者的血压特征。
S-HYPO 组与甲状腺功能正常组之间的诊室 SBP 和 DBP 无统计学差异（P＞0.05）。在动态血压水平上，S-HYPO 组的日间 SBP、夜间 SBP、夜间 SBP、24 小时 SBP 和 DBP 均显著高于甲状腺功能正常组（P＝0.048、P＝0.002、P＝0.003、P＝0.014、P＝0.046），且 S-HYPO 组非杓型血压的比例高于甲状腺功能正常组。联合诊室内外血压综合分析显示，S-HYPO 组与持续性高血压和隐匿性高血压独立相关，与白大衣高血压无关（P＝0.004、P＝0.002、P＝0.886）。在调整年龄、性别、BMI 等混杂因素后，上述差异仍有统计学意义（P＜0.05）。
通过联合诊室血压和动态血压，可以更准确地了解亚临床甲状腺功能减退症的血压特征。
