Department of Neurology, Brigham and Women's Hospital, Children's Hospital Computational Health Informatics Program, and Harvard Medical School, Boston, Massachusetts, USA.
Curr Opin Rheumatol. 2020 Nov;32(6):542-547. doi: 10.1097/BOR.0000000000000752.
To review the pathogenesis of inclusion body myositis (IBM).
IBM is an autoimmune disease. Multiple arms of the immune system are activated, but a direct attack on muscle fibers by highly differentiated T cells drives muscle destruction.
Further understanding of the pathogenesis of IBM guides rational approaches to developing therapeutic strategies.
综述包涵体肌炎（IBM）的发病机制。
IBM 是一种自身免疫性疾病。免疫系统的多个分支被激活，但高度分化的 T 细胞对肌纤维的直接攻击导致肌肉破坏。
对 IBM 发病机制的进一步了解指导了开发治疗策略的合理方法。
