辐射性肾病非人灵长类动物模型中细胞炎症的缺乏。
Lack of Cellular Inflammation in a Non-human Primate Model of Radiation Nephropathy.
机构信息
Departments of Medicine, University of Maryland, School of Medicine, Baltimore, MD.
Radiation Oncology, University of Maryland, School of Medicine, Baltimore, MD.
出版信息
Health Phys. 2020 Nov;119(5):588-593. doi: 10.1097/HP.0000000000001329.
Abstract
Inflammation is commonly cited as a mechanism of delayed effects of acute radiation exposure (DEARE). Confirmation of its presence could provide significant insight to targeted use of treatments or mitigators of DEARE. We sought to quantify the presence of cellular inflammation in kidneys of non-human primates that developed acute and chronic kidney injury after a partial body irradiation exposure. We show herein that cellular inflammation is not found as a component of either acute or chronic kidney injury. Other mechanistic pathways of injury must be sought.
摘要
炎症通常被认为是急性辐射暴露延迟效应（DEARE）的机制之一。确认其存在可以为靶向治疗或减轻 DEARE 提供重要的见解。我们试图定量分析部分身体辐射暴露后发生急性和慢性肾损伤的非人灵长类动物肾脏中细胞炎症的存在。本文表明，细胞炎症不是急性或慢性肾损伤的组成部分。必须寻找其他损伤的机制途径。
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