Department of Nuclear Medicine and Biomedical Research Institute, Pusan National University Hospital, Busan.
Department of Nuclear Medicine, College of Medicine, Pusan National University.
Nucl Med Commun. 2020 Dec;41(12):1313-1321. doi: 10.1097/MNM.0000000000001292.
The purpose of the current study was to investigate the diagnostic performance of F-18 fluorodeoxyglucose (FDG) PET/computed tomography (CT) for diagnosis of polymyalgia rheumatic (PMR) through a meta-analysis.
The PubMed, Cochrane and EMBASE database, from the earliest available date of indexing up to 29 February 2020, were searched for studies evaluating the diagnostic performance of F-18 FDG PET/CT for diagnosis of PMR.
Across the 11 results of seven studies selected for analysis (684 patients), the pooled sensitivity for F-18 FDG PET/CT was 0.76 [95% confidence interval (CI), 0.67-0.83] with heterogeneity (I = 74.9, P < 0.001) and a pooled specificity of 0.87 (95% CI, 0.82-0.91) with heterogeneity (I = 61.2, P < 0.001). Likelihood ratio syntheses gave an overall positive likelihood ratio of 5.7 (95% CI, 4.3-7.7) and negative likelihood ratio of 0.28 (95% CI, 0.2-0.38). The pooled diagnostic odds ratio was 21 (95% CI, 13-32). The hierarchical summary receiver operating characteristic curve indicated the areas under the curve as 0.93 (95% CI, 0.90-0.95).
The current meta-analysis showed a moderate sensitivity and specificity of F-18 FDG PET/CT for the diagnosis of PMR. Currently, the literature on the use of F-18 PET/CT for the diagnosis of PMR is limited. Thus, further large multicenter studies would be necessary to substantiate the diagnostic accuracy of F-18 FDG PET/CT for the detection of PMR.
本研究旨在通过荟萃分析探讨 18F 氟脱氧葡萄糖（FDG）PET/CT 对巨细胞动脉炎（PMR）的诊断性能。
检索 PubMed、Cochrane 和 EMBASE 数据库，检索时间从最早可追溯日期至 2020 年 2 月 29 日，评估 18F FDG PET/CT 诊断 PMR 的研究。
对纳入的 7 项研究共 684 例患者的 11 项结果进行分析，18F FDG PET/CT 的汇总敏感性为 0.76（95%CI，0.67-0.83），存在异质性（I=74.9，P<0.001），汇总特异性为 0.87（95%CI，0.82-0.91），存在异质性（I=61.2，P<0.001）。似然比综合分析得出的总阳性似然比为 5.7（95%CI，4.3-7.7），总阴性似然比为 0.28（95%CI，0.2-0.38）。汇总诊断优势比为 21（95%CI，13-32）。层次综合受试者工作特征曲线表明曲线下面积为 0.93（95%CI，0.90-0.95）。
本荟萃分析显示 18F FDG PET/CT 对 PMR 的诊断具有中等敏感性和特异性。目前，关于 18F PET/CT 用于 PMR 诊断的文献有限。因此，需要进一步开展多中心大样本研究，以证实 18F FDG PET/CT 对 PMR 检测的诊断准确性。
