18F-DCFPyL与18F-FDG PET/计算机断层扫描用于透明细胞肾细胞癌再分期的比较：15例患者的初步结果

Comparison of 18F-DCFPyL and 18F-FDG PET/computed tomography for the restaging of clear cell renal cell carcinoma: preliminary results of 15 patients.

作者信息

Liu Yachao, Wang Guanyun, Yu Hongkai, Wu Yue, Lin Mu, Gao Jiangping, Xu Baixuan

机构信息

Department of Nuclear Medicine.

Medical School of Chinese PLA, Beijing.

出版信息

Nucl Med Commun. 2020 Dec;41(12):1299-1305. doi: 10.1097/MNM.0000000000001285.

DOI:10.1097/MNM.0000000000001285

PMID:32941403

Abstract

OBJECTIVES

This study aimed to compare the diagnostic performance of F-DCFPyL and 2-deoxy-2-[F]fluoro-D-glucose (F-FDG PET/computed tomography in the restaging of clear cell renal cell carcinoma after nephrectomy.

METHODS

In this retrospective study, a total of 15 patients with suspected local recurrence of clear cell renal cell carcinoma or metastasis after surgery underwent both F-DCFPyL and F-FDG PET/computed tomography. A systematic comparison of the maximum standardized uptake value and the target to background ratio was carried out between the lesions detected by the two tracers.

RESULTS

A total of 42 lesions were detected either by F-DCFPyL PET/computed tomography or by F-FDG PET/computed tomography. F-DCFPyL PET/computed tomography, but not F-FDG PET/computed tomography, accurately distinguished the two local recurrence from four postoperative changes. The remaining 36 lesions were soft tissue (14) and bone lesions (22); all 36 lesions were detected by F-DCFPyL PET/computed tomography while only 10 (10/14) soft tissue lesions and 12 (12/22) bone lesions were detected by F-FDG PET/computed tomography. The higher detection rate of soft tissue lesions using F-DCFPyL PET/computed tomography was not statistically significant (P = 0.125); however, F-DCFPyL PET/computed tomography was statistically better (P = 0.002) at detecting bone lesions. The average maximum standardized uptake value and target to background ratio of F-DCFPyL were significantly higher than that of F-FDG for soft tissue lesions (maximum standardized uptake value P = 0.005; target to background ratio P = 0.028) and bone lesions (maximum standardized uptake value P = 0.001; target to background ratio P = 0.001).

CONCLUSIONS

Our preliminary results indicated that F-DCFPyL PET/computed tomography is superior to F-FDG PET/computed tomography for the detection of local recurrence at both the surgical site and in bone metastasis while the tracers are comparable in the detection of soft tissue metastases.

摘要

目的

本研究旨在比较F-DCFPyL与2-脱氧-2-[F]氟-D-葡萄糖（F-FDG）PET/计算机断层扫描在肾细胞癌肾切除术后再分期中的诊断性能。

方法

在这项回顾性研究中，共有15例疑似肾细胞癌局部复发或术后转移的患者接受了F-DCFPyL和F-FDG PET/计算机断层扫描。对两种示踪剂检测到的病变之间的最大标准化摄取值和靶本比进行了系统比较。

结果

F-DCFPyL PET/计算机断层扫描或F-FDG PET/计算机断层扫描共检测到42个病变。F-DCFPyL PET/计算机断层扫描能准确区分出两个局部复发与四个术后改变，而F-FDG PET/计算机断层扫描则不能。其余36个病变为软组织（14个）和骨病变（22个）；F-DCFPyL PET/计算机断层扫描检测到了所有36个病变，而F-FDG PET/计算机断层扫描仅检测到10个（10/14）软组织病变和12个（12/22）骨病变。F-DCFPyL PET/计算机断层扫描对软组织病变的较高检出率无统计学意义（P = 0.125）；然而，F-DCFPyL PET/计算机断层扫描在检测骨病变方面在统计学上更优（P = 0.002）。对于软组织病变（最大标准化摄取值P = 0.005；靶本比P = 0.028）和骨病变（最大标准化摄取值P = 0.001；靶本比P = 0.001），F-DCFPyL的平均最大标准化摄取值和靶本比显著高于F-FDG。