Department of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan.
Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital, Sapporo, Hokkaido, Japan.
PLoS One. 2020 Sep 17;15(9):e0232808. doi: 10.1371/journal.pone.0232808. eCollection 2020.
Studies on evoked responses in Parkinson's disease (PD) may be useful for elucidating the etiology and quantitative evaluation of PD. However, in previous studies, the association between evoked responses and detailed motor symptoms or cognitive functions has not been clear. This study investigated the characteristics of the visual (VEF), auditory (AEF), and somatosensory (SEF) evoked magnetic fields in patients with Parkinson's disease (PD), and the correlations between evoked fields and the patient's clinical characteristics, motor symptoms, and cognitive functions. Twenty patients with PD and 10 healthy controls (HCs) were recruited as participants. We recorded VEF, AEF, and SEF, collected clinical characteristics, performed physical examinations, and administered 10 cognitive tests. We investigated differences in the latencies of the evoked fields between patients with PD and HCs. We also evaluated the correlation of the latencies with motor symptoms and cognitive functioning. There were significant differences between the two groups in 6 of the cognitive tests, all of which suggested mild cognitive impairment in patients with PD. The latencies of the VEF N75m, P100m, N145m, AEF P50m, P100m, and SEF P60m components were greater in the patients with PD than in the HCs. The latencies mainly correlated with medication and motor symptoms, less so with cognitive tests, with some elements of the correlations remaining significant after Bonferroni correction. In conclusion, the latencies of the VEF, AEF, and SEF were greater in PD patients than in HCs and were mainly correlated with medication and motor symptoms rather than cognitive functioning. Findings from this study suggest that evoked fields may reflect basal ganglia functioning and are candidates for assessing motor symptoms or the therapeutic effects of medication in patients with PD.
帕金森病（PD）诱发电位的研究可能有助于阐明 PD 的病因和定量评估。然而，在以前的研究中，诱发电位与详细的运动症状或认知功能之间的关系尚不清楚。本研究探讨了帕金森病（PD）患者视觉（VEF）、听觉（AEF）和体感（SEF）诱发电磁场的特征，以及诱发电场与患者临床特征、运动症状和认知功能的相关性。招募了 20 名 PD 患者和 10 名健康对照者（HCs）作为参与者。我们记录了 VEF、AEF 和 SEF，收集了临床特征，进行了体格检查，并进行了 10 项认知测试。我们研究了 PD 患者与 HCs 之间诱发电场潜伏期的差异。我们还评估了潜伏期与运动症状和认知功能的相关性。在 10 项认知测试中有 6 项在两组之间存在显著差异，所有这些测试都表明 PD 患者存在轻度认知障碍。PD 患者的 VEF N75m、P100m、N145m、AEF P50m、P100m 和 SEF P60m 成分潜伏期大于 HCs。潜伏期主要与药物治疗和运动症状相关，与认知测试相关性较小，经 Bonferroni 校正后，部分相关性仍有统计学意义。总之，PD 患者的 VEF、AEF 和 SEF 潜伏期大于 HCs，主要与药物治疗和运动症状相关，而与认知功能相关性较小。本研究结果表明，诱发电位可能反映基底节功能，可作为评估 PD 患者运动症状或药物治疗效果的候选指标。
