Pekkonen E, Ahveninen J, Virtanen J, Teräväinen H
Department of Neurology, University of Helsinki, Finland.
Neuroreport. 1998 Sep 14;9(13):2949-52. doi: 10.1097/00001756-199809140-00006.
Auditory stimuli elicit auditory evoked magnetic fields (AEFs) called P50m and N100m, which index preconscious auditory processing in human. We investigated with a whole-head magnetometer whether Parkinson's disease (PD) impairs parallel preattentive auditory processing between the hemispheres. Stimulus blocks consisting of standard (80%) and deviant (20%) tones were monaurally presented in a passive condition to 11 PD patients with unilateral motor symptoms and to 11 age-matched healthy controls. The constant interstimulus intervals (ISIs) were 0.5 s and 2.5 s in separate blocks. The interhemispheric latency differences of the P50m and N100m were significantly lengthened in PD patients in the left-ear condition. This might be caused by the basal ganglia dysfunction in PD together with the simultaneous age-related neural degeneration predominant in the left auditory cortex.
听觉刺激会引发称为P50m和N100m的听觉诱发磁场（AEF），它们是人类潜意识听觉处理的指标。我们使用全头磁强计研究了帕金森病（PD）是否会损害半球间平行的前注意听觉处理。由标准音（80%）和偏差音（20%）组成的刺激块在被动条件下单耳呈现给11名有单侧运动症状的PD患者和11名年龄匹配的健康对照者。在不同的组块中，恒定的刺激间隔（ISI）分别为0.5秒和2.5秒。在左耳条件下，PD患者中P50m和N100m的半球间潜伏期差异显著延长。这可能是由PD中的基底神经节功能障碍以及同时存在的以左侧听觉皮层为主的与年龄相关的神经退行性变所致。
