Obstetrics and Gynecology, Samsun Education and Research Hospital, Samsun, Turkey.
Department of Obstetrics and Gynecology, Düzce Üniversitesi Tip Fakültesi, Duzce, Turkey.
Z Geburtshilfe Neonatol. 2021 Jun;225(3):238-243. doi: 10.1055/a-1233-9084. Epub 2020 Sep 17.
Intrahepatic cholestasis of pregnancy is a pregnancy-specific liver disease that usually emerges during the third trimester of pregnancy. It is characterized by itching and elevated serum total bile acid levels, and it may lead to severe fetal complications. This study aimed to investigate the role of interleukin-8, a pro-inflammatory cytokine; interleukin-10, an anti-inflammatory cytokine; and melatonin in intrahepatic cholestasis of pregnancy.
This prospective, case-controlled study was conducted with 51 women with intrahepatic cholestasis of pregnancy (40 mild and 11 severe cases) and 43 healthy pregnant women. Serum interleukin-8, interleukin-10, and melatonin levels were evaluated.
Melatonin and interleukin -10 were significantly lower in subjects with intrahepatic cholestasis of pregnancy (p=0.001; p=0.001, respectively p<0.05). Interleukin-8 levels were found to be significantly higher in the cholestasis group than control group (p=0.001, p<0.05).
Because interleukin-8, interleukin-10, and melatonin were found to be significantly correlated with intrahepatic cholestasis of pregnancy, we believe this finding could shed light on the etiology of the disease.
妊娠肝内胆汁淤积症是一种妊娠特有的肝脏疾病，通常在妊娠晚期出现。其特征为瘙痒和血清总胆汁酸水平升高，并可能导致严重的胎儿并发症。本研究旨在探讨白细胞介素-8（一种促炎细胞因子）、白细胞介素-10（一种抗炎细胞因子）和褪黑素在妊娠肝内胆汁淤积症中的作用。
这是一项前瞻性、病例对照研究，共纳入 51 例妊娠肝内胆汁淤积症患者（40 例轻度和 11 例重度）和 43 例健康孕妇。评估了血清白细胞介素-8、白细胞介素-10 和褪黑素水平。
妊娠肝内胆汁淤积症患者的褪黑素和白细胞介素-10 水平显著降低（p=0.001；p=0.001，p<0.05）。胆汁淤积组白细胞介素-8 水平显著高于对照组（p=0.001，p<0.05）。
由于白细胞介素-8、白细胞介素-10 和褪黑素与妊娠肝内胆汁淤积症显著相关，我们认为这一发现可能有助于阐明该病的病因。
