Isfahan Cardiovascular Research Center, Genetics and Epigenetics Department, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan 8158388994, Iran.
Department of Psychiatry, School of Medicine and Behavioral Science Research Center, Isfahan University of Medical Science, Isfahan 8174673461, Iran.
Int J Mol Sci. 2020 Sep 15;21(18):6758. doi: 10.3390/ijms21186758.
(1) Background: Obesity and mood disorders are considered as the most prevalent morbidities in many countries. We suppose that epigenetic mechanisms may induce higher rates of obesity in subjects who suffer from mood disorders. In this systematic review, we focused on the potential roles of DNA methylation on mood disorders and obesity development. (2) Methods: This systematic review was conducted in accordance with the PRISMA statement and registered in Prospero. A systematic search was conducted in MEDLINE, Scopus, Web of Science, Cochrane Central database, EMBASE, and CINHAL. We also conducted a Grey literature search, such as Google Scholar. (3) Results: After deduplication, we identified 198 potentially related citations. Finally, ten unique studies met our inclusion criteria. We have found three overlap genes that show significant DNA methylation changes, both in obesity and depression. Pathway analysis interaction for , and confirmed the relation of these genes in both obesity and mood disorders. (4) Conclusions: While mechanisms linking both obesity and mood disorders to epigenetic response are still unknown, we have already known chronic inflammation induces a novel epigenetic program. As the results of gene enrichment, pathways analysis showed that and linked together by inflammatory pathways. Hypermethylation in these genes might play a crucial rule in the co-occurrence of obesity and mood disorders.
(1) 背景：肥胖和情绪障碍被认为是许多国家最普遍的病态。我们假设表观遗传机制可能会导致患有情绪障碍的人肥胖率更高。在这个系统综述中，我们专注于 DNA 甲基化在情绪障碍和肥胖发展中的潜在作用。
(2) 方法：这个系统综述是按照 PRISMA 声明进行的，并在 Prospero 中注册。我们在 MEDLINE、Scopus、Web of Science、Cochrane 中央数据库、EMBASE 和 CINHAL 中进行了系统搜索。我们还进行了灰色文献搜索，例如 Google Scholar。
(3) 结果：在去重后，我们确定了 198 篇潜在相关的引文。最后，有 10 项独特的研究符合我们的纳入标准。我们发现了三个重叠的基因，它们在肥胖和抑郁中都显示出显著的 DNA 甲基化变化。 、 和 的途径分析交互作用证实了这些基因在肥胖和情绪障碍中的关系。
(4) 结论：虽然将肥胖和情绪障碍联系起来的机制与表观遗传反应仍不清楚，但我们已经知道慢性炎症会引发新的表观遗传程序。作为基因富集的结果，途径分析表明 和 通过炎症途径联系在一起。这些基因的高甲基化可能在肥胖和情绪障碍的同时发生中起着至关重要的作用。
