Swiergiel Artur H, Juszczak Grzegorz R, Stankiewicz Adrian M
Mod Trends Pharmacopsychiatry. 2015;30:120-37. doi: 10.1159/000435937. Epub 2015 Sep 18.
The neurophysiological link between neuropathic pain and depression remains unknown despite evident high comorbidity of these two disorders. However, there is convincing evidence that genotype plays a role in both pain and depression. Using various types of genetic analysis - population genetics, cytogenetics and molecular technologies - specific genes have been implicated in mediating almost all aspects of nociception and mood disorders. The current review attempts to identify specific genes and epigenetic mechanisms common to both disorders. It is concluded that external and internal factors (inflammation, stress, gender, etc.) that contribute to the pathologies may do so through epigenetic mechanisms that may affect expression of these particular genes. The possible involvement of epigenetic regulation in pain and psychiatric disorders suggests that treatments targeting epigenetic mechanisms that mediate adverse life events should be considered.
尽管神经性疼痛和抑郁症这两种疾病的共病率明显很高，但其神经生理联系仍然不明。然而，有令人信服的证据表明，基因型在疼痛和抑郁中都起作用。通过使用各种类型的基因分析——群体遗传学、细胞遗传学和分子技术——特定基因已被认为几乎在伤害感受和情绪障碍的各个方面都起介导作用。本综述试图确定这两种疾病共有的特定基因和表观遗传机制。得出的结论是，导致这些疾病的外部和内部因素（炎症、压力、性别等）可能通过影响这些特定基因表达的表观遗传机制来起作用。表观遗传调控可能参与疼痛和精神疾病，这表明应考虑针对介导不良生活事件的表观遗传机制的治疗方法。
