Pons J C, Goujard J, Derbanne C, Tournaire M
Service de Gynécologie-Obstétrique, Hôpital A. Béclère, Clamart.
J Gynecol Obstet Biol Reprod (Paris). 1988;17(3):307-16.
This study analyses the outcome of 110 pregnancies that occurred in 57 patients who were exposed to DES (DiEthylStilboestrol) during their fetal life. The quantities of Distilbene that were received in the first trimester of the pregnancy were the same in France and in the United States. The obstetrical complications of exposure in utero to DES were identically the same in France and in the United States. Of particular note is the high level of extra-uterine pregnancies (15%) and of 1st and 2nd trimester miscarriages (42%). Only 41% of the population exposed to DES delivered a live baby. It is estimated that 80,000 women were exposed to it in France. Exposure in utero to DES has given rise to a public health problem.
本研究分析了57名在胎儿期接触己烯雌酚（DES）的患者所发生的110次妊娠结局。在法国和美国，妊娠头三个月所接触的己烯雌酚剂量相同。在法国和美国，子宫内接触DES的产科并发症完全相同。特别值得注意的是，宫外孕发生率较高（15%）以及孕早期和孕中期流产率较高（42%）。接触DES的人群中只有41%分娩出活婴。据估计，法国有8万名女性接触过DES。子宫内接触DES引发了一个公共卫生问题。
