Kelly K L, Rapport M D, DuPaul G J
Department of Psychiatry, State University of New York, Stony Brook 11794.
Int Clin Psychopharmacol. 1988 Apr;3(2):167-81. doi: 10.1097/00004850-198804000-00007.
The present study investigated the effects of methylphenidate (MPH) on the resting heart rate of 47 children with Attention Deficit Disorder/Hyperactivity. Children participated in a double-blind, placebo control, within subject (cross-over) design and received each of 5 doses of MPH in a counterbalanced sequence. A multi-step analysis was used to examine the dose-response relationship, contribution of pre-stimulus levels of HR (i.e. the initial value), and potential interaction between dosage and time on resting HR. Results indicated that higher dosages are linearly related to increasing levels of HR and that these effects are dependent upon both the initial HR value and the time course of the medication.
本研究调查了哌甲酯（MPH）对47名患有注意力缺陷多动障碍儿童静息心率的影响。儿童参与了一项双盲、安慰剂对照、受试者内（交叉）设计，并以平衡序列接受了5种剂量的MPH。采用多步分析来检验剂量反应关系、心率预刺激水平（即初始值）的贡献以及剂量与时间对静息心率的潜在相互作用。结果表明，较高剂量与心率水平的增加呈线性相关，且这些影响取决于初始心率值和药物的时间进程。
