Máca Jan, Káňová Marcela, Kula Roman, Ševčík Pavel
Vnitr Lek. 2020 Spring;66(2):63-70.
Oxygen is biologically vital element sustaining life. The tissue oxygen delivery is therefore precisely regulated. The degree of tissue oxygenation is estimated by measurement of oxygen blood level. The lack of oxygen on cellular and tissue level can lead to organ failure and life-threatening condition. Important adaptive processes are activated during the sublethal hypoxia with goal to preserve cellular and tissue functions. Inadequate effort to correct hypoxia can cause either disturbance of the adaptation or undesirable tissue hyperoxia. This fact is taken into account in two currently proposed concepts: (1) precise control of arterial oxemia and (2) permissive hypoxemia. Recent literature supports rather restrictive strategy of oxygen therapy in critical care.
氧气是维持生命的重要生物元素。因此，组织的氧气输送受到精确调节。通过测量血氧水平来估计组织的氧合程度。细胞和组织水平上的缺氧会导致器官衰竭和危及生命的状况。在亚致死性缺氧期间会激活重要的适应性过程，目的是维持细胞和组织功能。纠正缺氧的努力不足可能会导致适应障碍或不良的组织高氧状态。目前提出的两个概念考虑到了这一事实：（1）精确控制动脉血氧不足和（2）允许性低氧血症。最近的文献支持在重症监护中采取较为严格的氧疗策略。
