帕金森病患者躯干侧屈与前庭功能障碍的关系：一项临床研究。

The link between lateral trunk flexion in Parkinson's disease and vestibular dysfunction: a clinical study.

机构信息

Department of Neurology, Huzhou Central Hospital, Affiliated Central Hospital Huzhou University, Huzhou, Zhejiang, China.

Department of Neurology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.

出版信息

Int J Neurosci. 2021 Jun;131(6):521-526. doi: 10.1080/00207454.2020.1825419. Epub 2020 Sep 24.

DOI:10.1080/00207454.2020.1825419

PMID:32942935

Abstract

INTRODUCTION

Lateral trunk flexion (LTF) is a common postural deformity in Parkinson's disease (PD). Postural control is known to depend on visual, vestibular, and somatosensory information.

OBJECTIVES

This study aimed to investigate the relationship between vestibular dysfunction and postural abnormalities in PD patients with LTF.

METHODS

We enrolled a total of 19 PD patients with LTF (PD-LTF+) and 19 age- and sex-matched PD patients without LTF (PD-LTF-). All patients underwent vestibular tests, including spontaneous nystagmus, gaze-evoked nystagmus, ocular movements, optokinetic eye test, fast positioning maneuvers, and the bithermal caloric test.

RESULTS

Most of the PD-LTF + patients had abnormal vestibular function (11/19), while there were fewer vestibular function injuries in the control group (3/19). In PD-LTF + group, there were 5 patients (5/11, 45.5%) of peripheral vestibular dysfunction, 2 patients (2/11, 18.2%) of central vestibular damage, and 4 patients (4/11, 36.4%) of mixed injuries. The peripheral vestibular deficiencies could be either bilateral (4/9, 44.4%) or unilateral (5/9, 55.6%). The unilateral vestibular dysfunction was ipsilateral to the leaning side in 2 patients and contralateral to the leaning side in the other 3 patients.

CONCLUSION

Vestibular dysfunction may be an independent risk factor for LTF in PD patients.

摘要

简介

侧向躯干弯曲（LTF）是帕金森病（PD）的一种常见姿势畸形。众所周知，姿势控制依赖于视觉、前庭和躯体感觉信息。

目的

本研究旨在探讨 PD 患者伴 LTF 时前庭功能障碍与姿势异常的关系。

方法

共纳入 19 例伴 LTF 的 PD 患者（PD-LTF+）和 19 例年龄和性别匹配的无 LTF 的 PD 患者（PD-LTF-）。所有患者均接受了前庭测试，包括自发性眼球震颤、凝视诱发眼球震颤、眼球运动、视动眼试验、快速定位动作和双温冷热水试验。

结果

大多数 PD-LTF+患者存在异常的前庭功能（11/19），而对照组前庭功能损伤较少（3/19）。在 PD-LTF+组中，有 5 例（5/11，45.5%）为周围性前庭功能障碍，2 例（2/11，18.2%）为中枢性前庭损伤，4 例（4/11，36.4%）为混合性损伤。周围性前庭缺陷可以是双侧（4/9，44.4%）或单侧（5/9，55.6%）。2 例单侧前庭功能障碍与倾斜侧同侧，另 3 例与倾斜侧对侧。