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作为抗癌药物的喹啉和异喹啉在药物化学中的优势支架概述。

An Overview of Privileged Scaffold: Quinolines and Isoquinolines in Medicinal Chemistry as Anticancer Agents.

机构信息

Henan Provincial Key Laboratory of Children's Genetics and Metabolic Diseases, Zhengzhou Children's Hospital, Zhengzhou University, Zhengzhou 450018, China

Shri Maneklal M. Patel Institute of Sciences and Research, Kadi Sarva Vishwavidyalaya University, Gandhinagar, Gujarat 362024, India

出版信息

Curr Top Med Chem. 2020;20(28):2599-2633. doi: 10.2174/1568026620999200917154225.

Abstract

Cancer is one of the most difficult diseases and causes of death for many decades. Many pieces of research are continuously going on to get a solution for cancer. Quinoline and isoquinoline derivatives have shown their possibilities to work as an antitumor agent in anticancer treatment. The members of this privileged scaffold quinoline and isoquinoline have shown their controlling impacts on cancer treatment through various modes. In particular, this review suggests the current scenario of quinoline and isoquinoline derivatives as antitumor agents and refine the path of these derivatives to find and develop new drugs against an evil known as cancer.

摘要

癌症是几十年来最困难的疾病和死亡原因之一。许多研究仍在不断进行,以寻找癌症的解决方案。喹啉和异喹啉衍生物已显示出作为抗癌治疗中的抗肿瘤剂的可能性。这个特权支架的成员喹啉和异喹啉通过各种模式显示了它们对癌症治疗的控制作用。特别是,本综述提出了喹啉和异喹啉衍生物作为抗肿瘤剂的当前情况,并完善了这些衍生物的途径,以发现和开发针对这种被称为癌症的恶性肿瘤的新药。

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