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成人组织细胞增生症的治疗要点：朗格汉斯细胞组织细胞增生症、 Erdheim-Chester 病、Rosai-Dorfman 病和噬血细胞性淋巴组织细胞增生症。

Highlights of the Management of Adult Histiocytic Disorders: Langerhans Cell Histiocytosis, Erdheim-Chester Disease, Rosai-Dorfman Disease, and Hemophagocytic Lymphohistiocytosis.

机构信息

Department of Oncology, King Abdul-Aziz Medical City, Riyadh, Saudi Arabia; King Saud bin Abdul-Aziz University for Health Science, College of Medicine, Riyadh, Saudi Arabia.

Department of Oncology, King Abdul-Aziz Medical City, Riyadh, Saudi Arabia; King Saud bin Abdul-Aziz University for Health Science, College of Medicine, Riyadh, Saudi Arabia.

出版信息

Clin Lymphoma Myeloma Leuk. 2021 Jan;21(1):e66-e75. doi: 10.1016/j.clml.2020.08.007. Epub 2020 Aug 18.

DOI:10.1016/j.clml.2020.08.007
PMID:32943371
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7434330/
Abstract

Histiocytic disorders are an exceptionally rare group of diseases with diverse manifestations and a paucity of approved treatments, thereby leading to various challenges in their diagnosis and management. With the discovery of novel molecular targets and the incorporation of targeted agents in the management of various adult histiocytic disorders, their management has become increasingly complex. In an attempt to improve the understanding of the clinical features and management of common adult histiocytic disorders (Langerhans cell histiocytosis, Erdheim-Chester disease, Rosai-Dorfman disease, and hemophagocytic lymphohistiocytosis), we created this document based on existing literature and expert opinion.

摘要

组织细胞疾病是一组非常罕见的疾病，具有多种表现形式，且缺乏已批准的治疗方法，因此在诊断和治疗方面存在各种挑战。随着新型分子靶点的发现以及靶向药物在各种成人组织细胞疾病治疗中的应用，其治疗变得越来越复杂。为了提高对常见成人组织细胞疾病（朗格汉斯细胞组织细胞增生症、 Erdheim-Chester 病、Rosai-Dorfman 病和噬血细胞性淋巴组织细胞增多症）的临床特征和治疗的认识，我们根据现有文献和专家意见编写了这份文件。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c78a/7434330/28891895d613/gr4_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c78a/7434330/95de840ea3d0/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c78a/7434330/813fef728cca/gr2_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c78a/7434330/0a2da77c113b/gr3_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c78a/7434330/28891895d613/gr4_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c78a/7434330/95de840ea3d0/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c78a/7434330/813fef728cca/gr2_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c78a/7434330/0a2da77c113b/gr3_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c78a/7434330/28891895d613/gr4_lrg.jpg

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Am J Hematol. 2021 May 1;96(5):E146-E150. doi: 10.1002/ajh.26119. Epub 2021 Feb 19.
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Could hemophagocytic lymphohistiocytosis be the core issue of severe COVID-19 cases?噬血细胞性淋巴组织细胞增生症是否为重症 COVID-19 病例的核心问题？
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病例报告：头皮原发性伴颅内累及的罗萨伊-多夫曼-德斯顿贝斯病：1例罕见病例的诊断与治疗并文献复习
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Advances in allogeneic hematopoietic stem cell transplantation for Langerhans cell histiocytosis in children.儿童朗格汉斯细胞组织细胞增多症异基因造血干细胞移植的进展
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