混合性组织细胞增生症：先天还是后天？
Mixed histiocytic disorders: Nature versus nurture?
机构信息
Baylor College of Medicine, Texas Children's Cancer and Hematology Centers, Houston, Texas, USA.
Wayne State University School of Medicine, Detroit, Michigan, USA.
出版信息
Br J Haematol. 2024 Jul;205(1):20-21. doi: 10.1111/bjh.19511. Epub 2024 May 19.
Histiocytic diseases arise from MAPK mutations in myeloid progenitors. Depending on whether the progenitor follows a dendritic cell or macrophage/monocyte lineage the final histology results in Langerhans cell histiocytosis, Rosai-Dorfman disease or Erdheim-Chester disease. Commentary on: Friedman et al. Mixed histiocytic neoplasms: A multicentre series revealing diverse somatic mutations and responses to targeted therapy. Br J Haematol 2024;205:127-137.
组织细胞疾病源于髓系前体细胞中 MAPK 的突变。根据前体细胞遵循树突状细胞还是巨噬细胞/单核细胞谱系，最终的组织学结果分别为朗格汉斯细胞组织细胞增生症、罗斯氏-多夫曼病或 Erdheim-Chester 病。述评：Friedman 等人。混合组织细胞肿瘤：揭示多种体细胞突变和对靶向治疗反应的多中心系列研究。《英国血液学杂志》2024；205：127-137。
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