Ahmadpour Doryaneh, Ahmadpoor Pedram, Rostaing Lionel
Department of Nephrology, Dialysis and Apheresis, Nîmes University Hospital Center, Nîmes, France.
Iran J Kidney Dis. 2020 Sep;14(5):331-334.
Coronavirus family has caused several human illnesses, the latest caused by SARS-CoV-2, has led to COVID-19 pandemic posing serious threat to global health. A SARS-CoV-2 variant encoding a D614G mutation in the viral spike (S) protein has now become the most prevalent form of the virus worldwide, suggesting a fitness advantage for the mutant. The G614 variant is associated with higher upper respiratory tract viral load, higher infectivity, increased total S protein incorporation into the virion, reduced S1 shedding and a conformational change leading to a more ACE2- binding and fusion- competent state. However, it does not seem to be correlated to increased disease severity or escape neutralizing antibodies.
冠状病毒家族已引发多种人类疾病，最新的由严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引起，导致了2019冠状病毒病大流行，对全球健康构成严重威胁。一种在病毒刺突（S）蛋白中编码D614G突变的SARS-CoV-2变体现已成为全球该病毒最普遍的形式，这表明该突变体具有适应性优势。G614变体与更高的上呼吸道病毒载量、更高的传染性、更多的总S蛋白掺入病毒粒子、减少的S1脱落以及导致更易于与血管紧张素转换酶2（ACE2）结合并具有融合能力状态的构象变化有关。然而，它似乎与疾病严重程度增加或逃避中和抗体无关。
