Division of Nephrology, Guilan University of Medical Sciences, Rasht, Iran.
Iran J Kidney Dis. 2020 Sep;14(5):405-411.
Renal transplantation can lead to or be associated with Low bone mineral density (BMD). The aim of this study is evaluation of BMD and related factors in our renal transplant patients.
In this descriptive cross-sectional analytical study, 148 kidney transplant patients from university hospital, were enrolled. BMD of hip and lumbar spine was measured by dual-energy X-ray absorptiometry (DXA) and patients were divided into 3 groups: normal, osteopenia, and osteoporosis; according to T-score. Laboratory parameters and a series of variables were investigated, and the results were compared with BMD findings.
In this study, 73 patients (49.3%) had osteopenia and 28 patients (18.9%) were osteoporotic. BMI was significantly lower in the osteoporosis group compared with the normal group (P < .05). Cumulative dose of prednisolone and calcium supplement were higher in osteoporotic group compared with normal group.
According to our results, osteoporotic and osteopenia groups have lower BMI that is associated with lower BMD. This can lead to increased risk of bone fractures in the future. Early discontinuation or reduction of prednisolone dose can improve BMD.
肾移植可导致或伴发低骨密度（BMD）。本研究旨在评估我院肾移植患者的 BMD 及相关因素。
本研究为描述性的横断面分析研究，共纳入 148 例来自大学医院的肾移植患者。采用双能 X 线吸收法（DXA）测量髋部和腰椎的 BMD，并根据 T 评分将患者分为 3 组：正常、骨量减少和骨质疏松。研究调查了实验室参数和一系列变量，并将结果与 BMD 结果进行比较。
本研究中，73 例（49.3%）患者存在骨量减少，28 例（18.9%）患者为骨质疏松。与正常组相比，骨质疏松组的 BMI 显著较低（P<.05）。与正常组相比，骨质疏松组累积泼尼松剂量和钙补充剂更高。
根据我们的结果，骨质疏松和骨量减少组的 BMI 较低，与较低的 BMD 相关。这可能会增加未来骨折的风险。早期停用或减少泼尼松剂量可改善 BMD。
