Grenabo L, Hedelin H, Hugosson J, Pettersson S
Department of Urology, Sahlgrenska sjukhuset, University of Göteborg, Sweden.
J Urol. 1988 Aug;140(2):428-30. doi: 10.1016/s0022-5347(17)41650-8.
Apart from urine supersaturation with respect to struvite and calcium phosphate, crystal retention is considered to be necessary for the formation of infection stones. This study was performed to investigate the role of the mucous coat in rat bladders in the adhesion of sterile urease-induced crystals and to determine to what extent the adhesion was influenced by infection. Elimination of the mucous coat with 0.1 M HCl increased the adherence of crystals six times compared to that in bladders with an intact mucous coat. Infection with Proteus mirabilis, Escherichia coli, enterococci and Ureaplasma urealyticum increased the adherence six, five, four and two times, respectively. Injury to the mucous coat may thus be one mechanism by which microorganisms can contribute to the formation of infection stones in the urinary tract.
除了尿液中磷酸铵镁和磷酸钙的过饱和状态外，晶体滞留被认为是感染性结石形成所必需的。本研究旨在探讨大鼠膀胱黏膜层在无菌尿素酶诱导的晶体黏附中的作用，并确定感染对这种黏附的影响程度。用0.1 M盐酸去除黏膜层后，晶体的黏附力比黏膜层完整的膀胱增加了六倍。奇异变形杆菌、大肠埃希菌、肠球菌和解脲脲原体感染分别使黏附力增加了六倍、五倍、四倍和两倍。因此，黏膜层损伤可能是微生物导致尿路中感染性结石形成的一种机制。
