Satoh M, Munakata K, Kitoh K, Takeuchi H, Yoshida O
J Urol. 1984 Dec;132(6):1247-9. doi: 10.1016/s0022-5347(17)50115-9.
A newly designed urolithiasis model for rats, inducing a mild urinary tract infection, exhibiting reduced renal damage without pyelonephritis and causing reliable stone formation, was established. This was accomplished by implanting a zinc disc in the bladder and then performing transvesical inoculation of Proteus mirabilis into the bladder. Five days after challenge with 10(7) colony forming units (CFU) of P. mirabilis in each rat, the number of organisms in the bladder urine reached a level of over 10(5) colony forming units per ml. The infection was mostly restricted to the urinary tract organs. Infectious bladder stones were formed 5 days after infection and developed day by day, weighing 88.3 +/- 18.8 mg. on the 21st day. Blood urea nitrogen values stayed in the normal range in all test animals during this experiment. The main composition of the stones formed was shown to be struvite (MgNH4PO4 X 6H2O).
建立了一种新设计的大鼠尿路结石模型，该模型诱发轻度尿路感染，在无肾盂肾炎的情况下肾损伤减轻，并能可靠地形成结石。这是通过在膀胱中植入锌盘，然后经膀胱将奇异变形杆菌接种到膀胱中来实现的。每只大鼠用10(7) 个奇异变形杆菌菌落形成单位（CFU）攻击后5天，膀胱尿液中的细菌数量达到每毫升超过10(5) 个菌落形成单位的水平。感染大多局限于泌尿器官。感染后5天形成感染性膀胱结石，并逐日发展，在第21天时重88.3±18.8毫克。在该实验过程中，所有试验动物的血尿素氮值均保持在正常范围内。所形成结石的主要成分显示为鸟粪石（MgNH4PO4·6H2O）。
