Pancewicz Joanna
Department of Histology and Embryology, Medical University of Bialystok, Bialystok, Poland.
Mol Cell Oncol. 2020 Jun 30;7(5):1776084. doi: 10.1080/23723556.2020.1776084. eCollection 2020.
The Notch pathway is an essential signaling system allowing neighboring cells to communicate and accomplish their proper developmental role in physiological condition. Nevertheless, there are many controversies conferring its function in pathological condition, particularly in cancer. It has been discovered that epigenetic regulation, posttranslational modifications, gene overexpression, and mutations may lead to the dysregulation of the Notch pathway. Additionally, Notch-mediated signaling can support tumor-suppressing mechanisms in certain types of cancer or may have oncogenic functions in others. Notch2 is one of the receptors commonly expressed in a variety of cancer cells, including gastric, hematological, and lung cancer. Moreover, it can be dysregulated in other diseases. In efforts to explain the role of Notch2 in the pathogenesis of cancer, recent studies indicated an association between this receptor and dysregulation of miRNAs, tumor-associated stromal cell, and modulation in tumor cells. Consequently, Notch2 function in the carcinogenesis process is unquestionable, whereas information according to the effect of its inhibition in tumor is still obscure. Hence, the aim of our study was to evaluate the current state of knowledge conferring Notch2 inhibition, with a particular focus on its role in cancer.
Notch信号通路是一种重要的信号系统，可使相邻细胞进行通讯，并在生理状态下发挥其正常的发育作用。然而，关于其在病理状态下，尤其是在癌症中的功能，仍存在许多争议。现已发现，表观遗传调控、翻译后修饰、基因过表达和突变可能导致Notch信号通路失调。此外，Notch介导的信号传导在某些类型的癌症中可能支持肿瘤抑制机制，而在其他癌症中可能具有致癌功能。Notch2是一种在多种癌细胞中普遍表达的受体，包括胃癌、血液系统癌症和肺癌。此外，它在其他疾病中也可能失调。为了解释Notch2在癌症发病机制中的作用，最近的研究表明该受体与miRNA失调、肿瘤相关基质细胞以及肿瘤细胞中的调节有关。因此，Notch2在致癌过程中的作用是毋庸置疑的，而关于其抑制对肿瘤影响的信息仍不清楚。因此，我们研究的目的是评估目前关于Notch2抑制的知识状态，特别关注其在癌症中的作用。
