Marchetto Aruna, Grünewald Thomas G P
Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Division of Translational Pediatric Sarcoma Research, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany.
Mol Cell Oncol. 2020 Jul 14;7(5):1783081. doi: 10.1080/23723556.2020.1783081. eCollection 2020.
Developmental pathways play an important role in cancer. We have recently demonstrated that the constitutive activation of the developmental transcription factor SOX6 via the fusion oncoproteinne EWSR1-FLI1 (Ewing sarcoma breakpoint region 1 - Friend leukemia virus integration 1) contributes to the aggressive phenotype of Ewing sarcoma but on another hand provides an opportunity for targeted therapy.
发育途径在癌症中起着重要作用。我们最近证明，通过融合癌蛋白EWSR1-FLI1（尤因肉瘤断点区域1-弗瑞德白血病病毒整合1）对发育转录因子SOX6的组成性激活有助于尤因肉瘤的侵袭性表型，但另一方面也为靶向治疗提供了机会。
