新冠病毒感染后继发炎症综合征，表现为难治性癫痫持续状态。
Post-COVID-19 inflammatory syndrome manifesting as refractory status epilepticus.
机构信息
Department of Neurology, NYU Langone Medical Center, New York, New York.
Department of Medicine, NYU Langone Medical Center, New York, New York.
出版信息
Epilepsia. 2020 Oct;61(10):e135-e139. doi: 10.1111/epi.16683. Epub 2020 Sep 18.
Abstract
There have been multiple descriptions of seizures during the acute infectious period in patients with COVID-19. However, there have been no reports of status epilepticus after recovery from COVID-19 infection. Herein, we discuss a patient with refractory status epilepticus 6 weeks after initial infection with COVID-19. Extensive workup demonstrated elevated inflammatory markers, recurrence of a positive nasopharyngeal SARS-CoV-2 polymerase chain reaction, and hippocampal atrophy. Postinfectious inflammation may have triggered refractory status epilepticus in a manner similar to the multisystemic inflammatory syndrome observed in children after COVID-19.
摘要
已有多篇文献描述过 COVID-19 患者在急性感染期发生癫痫发作的情况。然而，目前尚无 COVID-19 感染恢复后出现癫痫持续状态的报告。在此，我们讨论了 1 例 COVID-19 初始感染 6 周后出现难治性癫痫持续状态的患者。广泛的检查结果显示炎症标志物升高、鼻咽 SARS-CoV-2 聚合酶链反应再次阳性，以及海马萎缩。感染后炎症可能以类似于 COVID-19 后儿童中观察到的多系统炎症综合征的方式引发难治性癫痫持续状态。
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