Departamento De Ciencias Químico Biológicas Universidad De Sonora , Hermosillo, Sonora, México.
Expert Rev Vaccines. 2020 Sep;19(9):831-841. doi: 10.1080/14760584.2020.1825950. Epub 2020 Oct 8.
Tuberculosis (TB) is a major health problem worldwide. The BCG, the only authorized vaccine to fight TB, shows a variable protection in the adult population highlighting the need of a new vaccine. Immunoinformatics offers a variety of tools that can predict immunogenic T-cell peptides of () that can be used to create a new vaccine. Immunoinformatics has made possible the identification of immunogenic T-cell peptides of that have been tested showing a potential for using these molecules as part of a new TB vaccine.
This review summarizes the most common immunoinformatics tools to identify immunogenic T-cell peptides and presents a compilation about research studies that have identified T-cell peptides of by using immunoinformatics. Also, it is provided a summary of the TB vaccines undergoing clinical trials.
In the next few years, the field of peptide-based vaccines will keep growing along with the development of more efficient and sophisticated immunoinformatic tools to identify immunogenic peptides with a greater accuracy.
结核病（TB）是全球的一个主要健康问题。卡介苗（BCG）是唯一获准用于防治结核病的疫苗，但在成年人群中保护效果不一，这凸显了需要开发新疫苗。免疫信息学提供了多种工具，可以预测能够用于开发新疫苗的 （）的免疫原性 T 细胞肽。免疫信息学使得鉴定具有免疫原性的 T 细胞肽成为可能，这些肽已进行了 测试，显示出这些分子作为新的结核病疫苗的一部分的潜力。
本文综述了识别免疫原性 T 细胞肽的最常用免疫信息学工具，并介绍了使用免疫信息学鉴定 的 T 细胞肽的研究进展。此外，还提供了正在进行临床试验的结核病疫苗的概述。
在未来几年，随着更有效和复杂的免疫信息学工具的发展，以更准确地识别具有免疫原性的肽，基于肽的疫苗领域将不断发展。
