Nakarai H, Saida T, Shibata Y, Irie R F, Kano K
Int Arch Allergy Appl Immunol. 1987;83(2):160-6. doi: 10.1159/000234349.
Expression of heterophile antigens was studied on 6 human melanoma cell lines. Paul-Bunnell and Hanganutziu-Deicher (H-D) antigens, but not Forssman antigen, were demonstrated on these cell lines. H-D antigen was also demonstrated on melanoma cells isolated from primary and metastatic lesions. Evidence was also presented that HLA class I but not class II (DR and DQ) molecules are expressed on these cell lines. H-D antibodies of IgG class were detected in 10 of 23 (42%) melanoma patients suggesting the possibility that H-D antigen might have been expressed in an immunogenic form in the patients.
对6种人黑色素瘤细胞系的嗜异性抗原表达进行了研究。在这些细胞系上检测到了保罗-邦内尔抗原和汉加努齐乌-戴歇尔（H-D）抗原，但未检测到福斯曼抗原。从原发性和转移性病变中分离出的黑色素瘤细胞上也检测到了H-D抗原。有证据表明，这些细胞系上表达的是HLA I类分子而非II类（DR和DQ）分子。在23例黑色素瘤患者中的10例（42%）检测到了IgG类的H-D抗体，这表明H-D抗原可能在患者体内以免疫原性形式表达。
