人黑色素瘤组织神经节苷脂组分中的嗜异性汉氏-戴氏抗原
Heterophile Hanganutziu-Deicher antigen in ganglioside fractions of human melanoma tissues.
作者信息
Kawachi S, Saida T, Uhara H, Uemura K, Taketomi T, Kano K
机构信息
Department of Dermatology, Shinshu University School of Medicine, Matsumoto, Japan.
出版信息
Int Arch Allergy Appl Immunol. 1988;85(3):381-3. doi: 10.1159/000234536.
Gangliosides were purified from melanoma tissue extracts obtained from 5 patients. GM3 and GD3 were identified as the major components in ganglioside fractions of the melanoma tissues. Following thin-layer chromatography, enzyme immunostaining with Hanganutziu-Deicher (H-D) antigen-specific chicken antisera demonstrated the presence of NeuGc-neolactotetraosylceramide (H-D5) and NeuGc-lacto-N-norhexa-osylceramide (H-D7) in all 5 melanoma extracts.
从5例患者的黑色素瘤组织提取物中纯化神经节苷脂。GM3和GD3被鉴定为黑色素瘤组织神经节苷脂组分中的主要成分。薄层色谱后，用汉加努齐乌-戴歇尔（H-D）抗原特异性鸡抗血清进行酶免疫染色，结果显示在所有5份黑色素瘤提取物中均存在N-乙酰神经氨酸神经节四糖神经酰胺（H-D5）和N-乙酰神经氨酸乳糖-N-去甲六糖神经酰胺（H-D7）。
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